NIBIB National Centers Program

NIBIB P41 BTRR National Centers — Renewal

Funds national biomedical technology centers that build shared resources for advanced research infrastructure.

The NIBIB P41 Biomedical Technology Research Resource (BTRR) program supports a national network of centers that develop, apply, and disseminate specialized biomedical imaging and bioengineering technologies. These National Centers for Biomedical Imaging and Bioengineering (NCBIB) are expected to create and maintain critical and unique technology and methods, deploying them across basic, translational, and clinical research in partner institutions. The active funding opportunity is PAR-23-235 (Biomedical Technology Research Resource, P41 Clinical Trial Not Allowed), which runs on a continuous renewal cycle.

P41 awards are multi-component center grants typically funded at $1–2 million or more in direct costs per year for five-year project periods, renewable upon successful review. Eligible applicants are US academic and nonprofit research institutions; for-profit organizations and individual investigators are not eligible. NIBIB enforces caps on consecutive funding periods, and centers that have reached those limits must qualify under the separate New NIBIB P41 National Center pathway, which has distinct requirements documented in institute guidelines. The annual receipt date generally falls around May 25, though applicants must verify the specific FY2026 date on Grants.gov.

Competitive P41 applications require a technology development core, a set of collaborative research projects demonstrating broad use of the center's capabilities, and evidence of dissemination to the research community. NIBIB evaluates whether the proposed technology is genuinely unique and whether the center's infrastructure would be prohibitively difficult to replicate at individual investigator labs. Prospective applicants should review both the NIBIB guidelines for P41 National Centers and the separate requirements governing new versus renewal applications before beginning preparation.