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NIA R01: Drug Repositioning and Combination Therapy for Alzheimer's Disease

NIA R01: Drug Repositioning and Combination Therapy for Alzheimer's Disease

Funds researchers combining computational and experimental approaches to test repositioned drugs for Alzheimer's disease treatment through NIH R01 grants.

OpenNational Institute on AgingUnited States

The National Institute on Aging (NIA), part of the National Institutes of Health (NIH) under the Department of Health and Human Services, administers this R01 grant through the PAR-25-374 Notice of Funding Opportunity (NOFO). It sits under the ACTDRx AD (Advancing Combination Therapy and Drug Repurposing for Alzheimer's Disease) program, a cross-disciplinary initiative using translational bioinfor…

Translational bioinformatics and preclinical experimental work to identify and test drugs (individually or in combination) that may treat Alzheimer's disease and related dementias. Includes PK/PD modeling, mouse models, cell-based models, iPSCs, organoids, and non-pharmacologic interventions.

CycleiHow often this grant runs — e.g. annually, on a rolling basis, or a one-off call.Multiple per year
Next deadlineiThe next date applications are due. Rolling means you can apply any time.6 Oct 2026
Decision timeiTypical time from the deadline to the funder's decision.—
Project durationiHow long the funded work is expected to run.—
Award typeiThe form of funding — grant, equity, loan, tax credit, etc.Grant
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.0%
Funding pooliThe total budget available across all awards in this round.—

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Last verified: 5 Aug 2026Source: grants.nih.gov