Next-Generation Devices for Recording and Modulation in the Human CNS
Supports the development of next-generation neural devices for human neuroscience applications through collaborative research.
RFA-NS-25-021, administered by the NIH BRAIN Initiative with NINDS as lead Institute, funds UG3/UH3 two-phase cooperative agreements to develop next-generation devices for recording and modulating neural activity in the human central nervous system. The UG3 phase supports device development and engineering milestones, while the UH3 phase funds subsequent clinical studies in human subjects—advancem…
Funds UG3/UH3 two-phase cooperative agreements for developing and clinically translating next-generation devices for recording and modulating activity in the human central nervous system, led by NINDS.
Sign up free to see the funding breakdown
Sign up free to see the industries in scope
Sign up free to see the full eligibility
Sign up free to see the timeline
Guides for this application
All guides →NIH Biosketch Guide: Format, SciENcv Steps, and Examples
Learn what an NIH biosketch is, how the format works, what to prepare for SciENcv, and how startup teams should avoid common biosketch mistakes.
Write proposalHow to Write a Specific Aims Page
Learn how to write a specific aims page for NIH, SBIR-adjacent, and translational R&D grants, with structure, reviewer logic, examples, and common mistakes.
Submit & reportSAM.gov Registration and UEI Guide for Federal Grant Applicants
Learn how SAM.gov registration, UEI numbers, Grants.gov accounts, organization profiles, workspace roles, and renewal timing fit together.
BudgetIndirect Costs in Grants: Rates, MTDC, and Examples
Understand indirect costs in grants, including direct vs indirect costs, negotiated rates, de minimis rates, MTDC, funder caps, and budget narrative implications.
More from BRAIN Initiative
All grants from this funder →BRAIN Initiative Advanced Postdoctoral Career Transition Award to Promote Diversity
🇺🇸BRAIN Initiative · United States
Supports diverse early-career neuroscientists moving from mentorship to independent research leadership.
Preclinical Proof of Concept for Novel Recording/Modulation Technologies in Human CNS
🇺🇸BRAIN Initiative · United States
Funds preclinical testing for novel neural recording and modulation technologies before clinical transition.
Development and Validation of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in the Brain
BRAIN Initiative · United States
Funds new methods to study brain cells and circuits with tools for deeper neural research.
Brain Behavior Quantification and Synchronization — Next Gen Sensor Technology Development
🇺🇸BRAIN Initiative · United States
Supports neural behavior-sensing technology development through translational cooperative projects.
Reagent Resources for Brain Cell Type-Specific Access at MSIs/IDeA Institutions
🇺🇸BRAIN Initiative · United States
Funds production and distribution of brain cell-type-specific reagents to institutions with broad access goals.
Clinical Studies to Advance Next-Generation Devices for Recording/Modulation in Human CNS
🇺🇸BRAIN Initiative · United States
Funds human clinical studies of next-generation neural devices through research agreements.
Similar grants
Browse the directory →
BRAIN Initiative: Next-Generation Devices for Recording and Modulation in the Human Central Nervous System
🇺🇸NIH · United States
Funds taking a brain recording or stimulation device from prototype through safety testing and an FDA exemption into a first small clinical study.
BRAIN Initiative: Clinical Studies to Advance Next-Generation Devices for Recording and Modulation in the Human Central Nervous System
🇺🇸NIH · United States
Funds the small clinical trial that settles a brain device's final design — early feasibility studies, from short procedures to chronic implants.
NIH Blueprint MedTech Translator
🇺🇸NINDS · United States
Funds translational neurotechnology device development through structured milestones and multi-year collaboration.
BRAIN Initiative: Preclinical Proof of Concept for Novel Recording and Modulation Technologies in the Human CNS
🇺🇸NIH · United States
Funds a novel recording or modulation technology for the human central nervous system from proof of concept up to readiness for first-in-human studies.
First in Human and Early Stage Clinical Trials of Novel Investigational Drugs or Neuromodulatory Device-based Interventions for Psychiatric Disorders
🇺🇸NIH · United States
Funds the first human trials of a novel-mechanism psychiatric drug or a novel neuromodulatory device, with milestones gating each step.
Continuing Human Enabling Enhancing Restoring and Sustaining
🇺🇸AFRL · United States
Funds Air Force human-performance research, but only through the two grant-eligible solicitations sitting beneath this umbrella notice.