NCATS STTR Phase II
Funds U.S. small businesses and their nonprofit research partners to continue and expand translational R&D begun in STTR Phase I toward a commercial product.
NCATS STTR Phase II is the continuation grant that follows a successful STTR Phase I award. It funds the expansion of the R&D work initiated in Phase I, with the goal of producing a commercial product, process, or service. Awards are normally $2,095,748 in total costs over a two-year project period. Applications may exceed this amount with prior approval from the NCATS Grants Management Officer.
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Continuation of research and development from STTR Phase I, within NCATS's translational science mission: drug discovery, diagnostics, medical devices, informatics, and platform technologies. NCATS-specific priorities include rare diseases, toxicology, clinical trial innovation, and translational informatics. Phase II must continue work from a prior Phase I — it is not an entry-level grant.
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Guides for this application
All guides →SBIR/STTR Grants for Deeptech Startups
A practical guide to SBIR and STTR grants for deeptech startups, including agency fit, Phase I and II logic, eligibility, budgets, and review criteria.
DocumentsNIH Biosketch Guide: Format, SciENcv Steps, and Examples
Learn what an NIH biosketch is, how the format works, what to prepare for SciENcv, and how startup teams should avoid common biosketch mistakes.
Write proposalHow to Write a Specific Aims Page
Learn how to write a specific aims page for NIH, SBIR-adjacent, and translational R&D grants, with structure, reviewer logic, examples, and common mistakes.
Where to applyGrants for Biotech Startups: NIH, NSF, SBIR/STTR, and Non-Dilutive Funding
A practical guide to grants for biotech startups, including NIH SBIR/STTR, NSF, translational funding, evidence, regulatory readiness, and budgets.
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