NIAID Investigator-Initiated Program Project

NIAID Investigator-Initiated P01

Supports investigator-led infectious disease and immunology multi-project teams under NIAID.

PAR-27-082 is NIAID's standing Program Announcement with Special Receipt for investigator-initiated Program Project (P01) applications addressing the full scope of the National Institute of Allergy and Infectious Diseases mission. The announcement was posted May 7, 2026, last updated May 13, 2026, and remains open through May 25, 2029, with an archive date of July 24, 2029. Contact for applicants is NIAID_P01_NOFO@mail.nih.gov. Assistance Listing number is 93.855 (Allergy and Infectious Diseases Research). Receipt dates follow the standard NIH P01 schedule, typically three times per year in January, May, and September.

Each P01 application submitted under PAR-27-082 must include at minimum two related, synergistic Research Projects sharing a common central theme, focus, and/or overall objective, plus a mandatory Administrative Core. Applications may also include Scientific Cores when justified by the research plan. The NOFO covers five scientific priority areas: biology and pathogenesis of infectious microbes including HIV; host-microbe interactions; mechanisms regulating immune system development and function across the lifespan; immune dysfunction resulting in allergy, asthma, autoimmunity, immunodeficiency, or transplant rejection; and translational research to develop vaccines, therapeutics, and diagnostics for infectious and immune-mediated diseases. Clinical trials are not allowed under this announcement.

Domestic organizations across all types — universities, nonprofits, small businesses, for-profits, and state, county, city, and tribal governments — are eligible. Foreign organizations are not eligible to receive awards, although foreign components within a US-led application are permitted. Award amounts are not specified in the NOFO text; typical NIH P01 grants run approximately $1.5 million per year in direct costs, but applicants should contact the NIAID program office for current budget guidance before submission.