NIH SBIR Phase II
Supports United States biomedical small businesses advancing successful feasibility work into scale-up development.
NIH SBIR Phase II awards provide non-dilutive grant funding for small businesses to continue and scale the R&D work initiated under a Phase I award, with the goal of advancing innovations toward commercialization. The budget cap for Phase II is $2,153,927 for a project period of one to three years. Phase II applicants must have completed a Phase I award (or qualify for Direct-to-Phase II if feasib…
Continuation and scale-up of Phase I biomedical feasibility R&D toward commercialization, across all 24 participating NIH Institutes and Centers.
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Guides for this application
All guides →SBIR/STTR Grants for Deeptech Startups
A practical guide to SBIR and STTR grants for deeptech startups, including agency fit, Phase I and II logic, eligibility, budgets, and review criteria.
DocumentsNIH Biosketch Guide: Format, SciENcv Steps, and Examples
Learn what an NIH biosketch is, how the format works, what to prepare for SciENcv, and how startup teams should avoid common biosketch mistakes.
Write proposalHow to Write a Specific Aims Page
Learn how to write a specific aims page for NIH, SBIR-adjacent, and translational R&D grants, with structure, reviewer logic, examples, and common mistakes.
Where to applyGrants for Biotech Startups: NIH, NSF, SBIR/STTR, and Non-Dilutive Funding
A practical guide to grants for biotech startups, including NIH SBIR/STTR, NSF, translational funding, evidence, regulatory readiness, and budgets.
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