Major Projects

Major Projects is Alzheimer's Research UK's flagship investigator-led grant for intermediate-to-large dementia research. It sits above Pilot Projects in the charity's portfolio and is built for work that needs more time, more staff, and a broader scientific scope. The award provides up to GBP 750,000 over as long as five years, with timing set to scientific need. Funds can support postdoctoral and technical staff salaries, experimental running costs, equipment, and collaborative travel. Lead applicants must be based at a UK academic or research institution and hold a fixed-term or tenure contract that covers the full grant period. Co-applicants without tenure can join, while international collaborators and industry partners are permitted. Applications move through peer review, a rebuttal stage, lived-experience review, and Grant Review Board approval. The annual cycle opens in July, closes in October, and reaches decisions in the spring. This route suits teams that can justify a five-year workplan and defend why the work belongs at this scale rather than as a pilot. The strongest applications are likely to have a clear collaborative structure, a credible budget, and enough preliminary evidence to support a substantial research programme.

Each grant below is a distinct funding opportunity with its own eligibility, scope, and deliverables.