NIH NIBIB SBIR

NIH NIBIB SBIR is the small-business route of the National Institute of Biomedical Imaging and Bioengineering, an NIH institute within the U.S. Department of Health and Human Services. NIBIB’s mission is to transform understanding of disease and its prevention, detection, diagnosis, and treatment through technology development, and its scope runs across biomedical imaging, bioengineering, informatics, digital health, and small-business innovation. The program is grant-based, with awards in the structured record ranging from US$200,000 to US$2 million and a median actual award of US$400,000. It requires a U.S.-incorporated for-profit company, excludes nonprofits and individuals, and is aimed at TRL 2-7. The institute’s funding pages point to imaging, bioengineering, point-of-care diagnostics, and medical devices as the most relevant lanes, while the record also notes standard NIH due dates and multi-year receipt windows through 2025-2027. NIBIB’s broader funding style is partnership-heavy and milestone-driven, with BPI showing the same discipline through joint academic-industry roles, quantified milestones, and 5-10 year deliverables. Applications over US$500,000 in annual direct costs need a white paper, written NIBIB approval, and at least six weeks’ advance notice, so strong proposals usually combine a clear technical advance with a credible route to practical use.

No upcoming rounds verified. Cadence: Multiple per year.