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NCATS Preclinical Proof of Concept Studies for Rare Diseases

Funds U.S. researchers and companies conducting preclinical efficacy studies to advance therapeutic candidates for rare diseases toward IND applications.

National Center for Advancing Translational SciencesUnited StatesGrant

NCATS Preclinical Proof of Concept Studies for Rare Diseases is an R21 exploratory grant administered by the National Center for Advancing Translational Sciences (NCATS) under the NIH. The program operates under FOA RFA-TR-25-002 (reissue of RFA-TR-24-023). Awards cover up to $275,000 in direct costs over a two-year project period, with no more than $200,000 in any single year. NCATS intends to co…

BiotechMedtechSynthetic Biology

Each grant below is a distinct funding opportunity with its own eligibility, scope, and deliverables.

Last verified: 24 Jun 2026Source: grants.nih.gov