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Program

High-Risk, High-Reward Research (HRHR) Program

Funds unusually high-risk ideas with the potential for major scientific payoff.

NIH Common FundUnited States

High-Risk, High-Reward Research is a core NIH Common Fund program managed through the Office of Strategic Coordination in the Division of Program Coordination, Planning, and Strategic Coordination at the NIH Office of the Director. It supports unusually creative research with broad impact and is designed for ideas that are too early or too unconventional for standard peer review, with preliminary …

BiotechMedtechNeurotechAISynthetic Biology
Last verified: 29 May 2026Source: commonfund.nih.gov