NIH SBIR/STTR Commercialization Readiness Pilot (CRP) Program

NIH SEED's Commercialization Readiness Pilot, or CRP, is a follow-on funding route for SBIR and STTR awardees that need help moving a project beyond Phase II or Phase IIB Strategic Breakthrough support. It is designed for late-stage development and technical assistance rather than for first-time applicants. The program is limited to US for-profit businesses with an active or recent NIH SBIR or STTR Phase II or Phase IIB Strategic Breakthrough award from a participating institute or center within the last 36 months. Awards can reach $4,191,495 over as long as three years, only one CRP is allowed per project, and TABA funding cannot be requested inside a CRP application. This is the right route when the science is already de-risked enough to justify commercialization work, but the company still needs support for the final stretch. The program sits between standard small-business R&D funding and market entry, so the strongest applications will show a clear product path, a recent qualifying NIH award, and a concrete reason ordinary Phase II support is not enough. Because it is a continuation mechanism, it rewards continuity and evidence more than novelty.

Each grant below is a distinct funding opportunity with its own eligibility, scope, and deliverables.