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NIH HEAL Initiative

NIH HEAL Initiative — Open NOFOs

Supports opioid, pain, and substance use disorder research in the NIH HEAL portfolio.

Between cyclesNational Institutes of HealthUnited States
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About

The NIH HEAL (Helping to End Addiction Long-term) Initiative is a trans-NIH research portfolio addressing the national opioid overdose and pain management crisis, administered across multiple NIH Institutes and Centers rather than by a single IC. As of May 2026, HEAL has more than 20 active NOFOs with deadlines spanning July 2026 through August 2028, plus approximately 10 forecasted opportunities …

What this grant funds

Opioid overdose prevention, non-addictive pain management, substance use disorder treatment, analgesic drug discovery, and health services research across the NIH HEAL trans-agency portfolio.

Key facts
CycleiHow often this grant runs — e.g. annually, on a rolling basis, or a one-off call.Multiple per year
Next deadlineiThe next date applications are due. Rolling means you can apply any time.2 Oct 2026
Decision timeiTypical time from the deadline to the funder's decision.—
Project durationiHow long the funded work is expected to run.—
Award typeiThe form of funding — grant, equity, loan, tax credit, etc.Grant
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.0%
Funding pooliThe total budget available across all awards in this round.—
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Last verified: 30 Jul 2026Source: www.nih.gov