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Funder · Federal agency

National Institutes of Health

Funds biomedical research nationwide, supporting university, nonprofit, and small business projects across major health initiatives.

United States
Annual funding$35.3B
Programs152
Active grants261
Total grants456

National Institutes of Health (NIH) is the medical-research arm of the U.S. Department of Health and Human Services and the world's largest public funder of biomedical research. It sits in Bethesda and moves about $35.3 billion a year through 27 Institutes and Centers.

Its cross-IC routes include SBIR and STTR, parent R01, R03, and R21 announcements, the HEAL Initiative, and the NIH Common Fund. …

NIH Research Project Grant

Helps NIH Research Project Grant for established research programs for innovation and strategic advancement.

79 grants
Alcohol Treatment, Pharmacotherapy, and Recovery Research (R01)
Between cycles
$500K pool
Modular R01s in Cancer Control and Population Sciences
Open
- pool
Alcohol Health Services Research (R01)
Between cycles
$500K pool
NIH Research Project Grant
Open
- pool
Advancing Healthcare for Older Adults from Populations that Experience Health Disparities
Open
- pool
Clinical Observational (CO) Studies in Musculoskeletal, Rheumatic, and Skin Diseases
Open
- pool
Revision Applications for Validation of Biomarker Assays Developed Through NIH-Supported Research Grants
Open
- pool
Research Projects to Enhance Applicability of Mammalian Models for Translational Research
Between cycles
$499K pool
Molecular Imaging of Inflammation in Cancer
Open
$500K pool
Interventions to Reduce Sleep Health Disparities
Open
- pool
Cellular and Molecular Biology of Complex Brain Disorders (R01)
Between cycles
- pool
Schizophrenia and related disorders during mid- to late-life (R01)
Between cycles
- pool
Mechanisms that Impact Cancer Risk after Bariatric Surgery (R01)
Open
- pool
Novel Mechanism Research on Neuropsychiatric Symptoms (NPS) in Alzheimer's Dementia (R01)
Between cycles
- pool
Social disconnection and Suicide Risk in Late Life (R01)
Between cycles
- pool
Mechanisms that Impact Cancer Risk with Use of Incretin Mimetics (R01)
Open
- pool
CCRP Initiative: NIH Countermeasures Against Chemical Threats (CounterACT) Basic Research on Chemical Threats that Affect the Nervous System
Open
$300K pool
Academic-Industrial Partnerships (AIP) to Translate and Validate In Vivo Imaging Systems
Open
$500K pool
National Cancer Institute's Investigator-Initiated Early Phase Clinical Trials for Cancer Treatment and Diagnosis
Open
$500K pool
Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R01)
Open
$350K pool
Interventions to expand cancer screening and preventive services to ADVANCE health in populations that experience health disparities
Open
- pool
Computational Approaches to Curation at Scale for Biomedical Research Assets
Open
$250K pool
Laboratories to Optimize Digital Health
Open
- pool
Dissemination and Implementation Research in Health (R01)
Open
- pool
Clinical Characterization of Cancer Therapy-induced Adverse Sequelae and Mechanism-based Interventional Strategies
Open
- pool
Assay development and screening for discovery of chemical probes, drugs or immunomodulators
Between cycles
- pool
Cancer Prevention and Control Clinical Trials Grant Program
Open
- pool
Integration of Imaging and Fluid-Based Tumor Monitoring in Cancer Therapy
Open
$500K pool
Full-Scale Hybrid Effectiveness-Implementation Trials for Mental Health Interventions
Open
- pool
Pilot Hybrid Effectiveness-Implementation Trials for Mental Health Interventions
Open
- pool
Confirmatory Efficacy Clinical Trials of Non-Pharmacological and Pharmacological Interventions for Mental Disorders
Open
- pool
Screening and Functional Validation of Genomic Variants Associated with Human Congenital Anomalies
Open
- pool
Focused Technology Research and Development
Open
- pool
Pilot Effectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes
Open
- pool
Effectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes
Open
- pool
Population Approaches to Reducing Alcohol-related Cancer Risk
Open
- pool
Natural History of Disorders Screenable in the Newborn Period
Open
- pool
Investigator Initiated Innovation in Computational Genomics and Data Science (R01)
Open
- pool
Personal Health Informatics for Delivering Actionable Insights to Individuals
Open
- pool
Basic Research in Cancer Health Disparities (R01)
Open
- pool
Developing novel theory and methods for understanding the genetic architecture of complex human traits (R01)
Open
- pool
Innovative Screening Approaches and Therapies for Screenable Disorders in Newborns (R01)
Open
- pool
NCCIH Multi-Site Feasibility Clinical Trials of Mind and Body Interventions
Open
- pool
Investigator Initiated Clinical Trials of Complementary and Integrative Interventions Delivered Remotely or via mHealth
Open
- pool
NCCIH Natural Product Mid Phase Clinical Trial
Open
$350K pool
New Approaches for Measuring Brain Changes Across Longer Timespans (R01)
Open
- pool
Mood and Psychosis Symptoms during the Menopause Transition (R01)
Open
- pool
Innovative Mental Health Services Research Not Involving Clinical Trials
Open
- pool
Neuromodulation/Neurostimulation Device Development for Mental Health Applications (R01)
Open
- pool
Navigator Emergency Department Diversion Models for Non-Urgent Mental Health Concerns (R01)
Open
- pool
Utilizing Invasive Recording and Stimulating Opportunities in Humans to Advance Neural Circuitry Understanding of Mental Health Disorders (R01)
Open
- pool
Interventions to Address Disparities in Liver Diseases and Liver Cancer
Open
- pool
Accelerating Solutions to Improve Access and Quality of Empirically-Supported Practices for Youth Mental Health
Open
- pool
Risk and Protective Factors of Family Health and Family Level Interventions
Open
- pool
Stephen I. Katz Early Stage Investigator Research Project Grant
Open
- pool
Toward Translation of Nanotechnology Cancer Interventions (TTNCI)
Open
- pool
Academic-Industrial Partnerships for Translation of Technologies for Diagnosis and Treatment
Open
$499K pool
Early Immune System Development and Ontogeny
Open
- pool
Ethical, Legal and Social Implications (ELSI) Research
Open
- pool
Intervention Research to Improve Native American Health (R01)
Open
- pool
Screening, Brief Intervention and Referral to Treatment or Prevention (SBIRT/P) for alcohol, tobacco, and other drugs (ATOD) use and misuse in adult populations that experience health disparities
Open
- pool
Advancing Bioinformatics, Translational Bioinformatics and Computational Biology Research
Open
$2.5M pool
Research Grants in Clinical Informatics
Open
$2.5M pool
Bioengineering Research Grants (BRG)
Open
- pool
CCRP Initiative: Promoting a Basic Understanding of Chemical Threats to Skin
Open
- pool
Discovery of in vivo Chemical Probes for the Nervous System
Open
- pool
Stimulating Hematology Investigation: New Endeavors (SHINE)
Open
- pool
High Priority HIV and Substance Use Research (R01)
Open
- pool
Chemical Countermeasures Research Program (CCRP) Initiative: Basic Research on The Deleterious Effects of Acute Exposure to Ultra-Potent Synthetic (UPS) Opioids
Open
$300K pool
Accelerating the Pace of Substance Use Research Using Existing Data (R01)
Open
- pool
BRAIN Initiative: Theories, Models and Methods for Analysis of Complex Data from the Brain
Open
- pool
NIDCD Research Grants for Translating Basic Research into Clinical Practice
Open
$500K pool
In Vivo High-Resolution Imaging for Inner Ear Visualization
Closed
$500K pool
Transformative Non-Invasive/Minimally Invasive Technologies for Imaging the Olfactory System Across Scales (R01 CT Optional)
Open
$2M pool
Supporting Talented Early Career Researchers in Genomics
Open
- pool
BRAIN Initiative: Development and Validation of Novel Tools to Probe Cell-Specific and Circuit-Specific Processes in the Brain
Open
- pool
Addressing Methodological Challenges with Clinical Trials of Rapid-Acting Psychotropic Interventional Drugs (RAPIDs)
Open
$5.5M pool
Advancing Research on Empirically-Supported Interventions for Older Adults Living with Serious Mental Illness (SMI)
Open
$3M pool
INCLUDE Project: Transformative Research Awards for Down syndrome
Open
$3M pool
NIH Exploratory/Developmental Research Grant

Helps NIH Exploratory and Developmental Research Grant for novel ideas and preliminary studies.

30 grants
Exploratory Grants in Cancer Control
Open
- pool
NIH Exploratory/Developmental Research Project Grant
Open
- pool
Cellular and Molecular Biology of Complex Brain Disorders (R21)
Between cycles
- pool
Schizophrenia and related disorders during mid- to late-life (R21)
Between cycles
- pool
Mechanisms that Impact Cancer Risk after Bariatric Surgery (R21)
Open
- pool
Novel Mechanism Research on Neuropsychiatric Symptoms (NPS) in Alzheimer's Dementia (R21)
Between cycles
- pool
Social disconnection and Suicide Risk in Late Life (R21)
Between cycles
- pool
Pilot Studies of Biological, Behavioral and Social Mechanisms Contributing to HIV Pathogenesis Within the Mission of NIDDK
Open
- pool
Mechanisms that Impact Cancer Risk with Use of Incretin Mimetics (R21)
Open
- pool
Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R21)
Open
$200K pool
Cutting-Edge Basic Research Awards (CEBRA)
Open
$150K pool
NIDCD Early Career Research(ECR) Award
Open
- pool
Dissemination and Implementation Research in Health (R21)
Open
- pool
Investigator Initiated Innovation in Computational Genomics and Data Science (R21)
Closed
- pool
Basic Research in Cancer Health Disparities (R21)
Open
- pool
Developing novel theory and methods for understanding the genetic architecture of complex human traits (R21)
Open
- pool
Innovative Screening Approaches and Therapies for Screenable Disorders in Newborns (R21)
Open
$200K pool
New Approaches for Measuring Brain Changes Across Longer Timespans (R21)
Open
- pool
Development of Animal Models and Related Biological Materials for Research
Open
$200K pool
Mood and Psychosis Symptoms during the Menopause Transition (R21)
Open
- pool
Neuromodulation/Neurostimulation Device Development for Mental Health Applications (R21)
Open
- pool
Utilizing Invasive Recording and Stimulating Opportunities in Humans to Advance Neural Circuitry Understanding of Mental Health Disorders (R21)
Open
$200K pool
Exploratory/Developmental Bioengineering Research Grants (EBRG)
Open
- pool
NEI Research Grant for Vision-Related Secondary Data Analysis
Open
- pool
Ethical, Legal and Social Implications (ELSI) Exploratory/Developmental Research Grant
Open
- pool
Expanding the Target Landscape by Drugging the Undruggable
Open
- pool
Accelerating the Pace of Substance Use Research Using Existing Data (R21)
Open
- pool
Early-Stage Dissemination and Implementation Research in Communication Disorders
Open
$1M pool
Using Archived Data and Specimen Collections to Advance Maternal and Pediatric HIV/AIDS Research (R21 CT Not Allowed)
Open
$1M pool
INCLUDE Project: Exploratory/Developmental Research Awards for Down syndrome
Open
$1M pool
NIH Phase 1 Exploratory/Developmental Grant (R61)

Funds Phase 1 Exploratory/Developmental Grant, NIH's R61 mechanism.

22 grants
Exploratory Clinical Trial Grants in Arthritis and Musculoskeletal and Skin Diseases (R61)
Open
- pool
Development of Biomarkers or Composite Biomarkers for Neurological and Neuromuscular Disorders
Open
- pool
NHLBI Early Phase Clinical Trials for Therapeutics and/or Diagnostics for HLBS Disorders
Open
- pool
Translational Neural Devices
Open
- pool
Innovation Grants to Nurture Initial Translational Efforts (IGNITE): Assay Development and Neurotherapeutic Agent Identification
Open
$750K pool
Innovation Grants to Nurture Initial Translational Efforts (IGNITE): Development and Validation of Model Systems to Facilitate Neurotherapeutic Discovery
Open
$750K pool
Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R61/R33)
Open
- pool
Early Stage Testing of Pharmacologic or Neuromodulatory Device-based Interventions for the Treatment of Mental Disorders (R61/R33)
Open
- pool
Enhancing Mechanistic Research on Precision Probiotic Therapies (R61/R33)
Open
- pool
Innovation Grants to Nurture Initial Translational Efforts (IGNITE): Neurotherapeutic Agent Characterization and In vivo Efficacy Studies
Open
- pool
NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award
Open
$350K pool
Effectiveness Trials to Test Mental Health System Interventions
Open
- pool
Mind and Body Interventions to Restore Whole Person Health via Emotional Well-Being Mechanisms
Open
- pool
Single-Site Investigator-Initiated Clinical Trials
Open
- pool
Early-Stage Innovative Technology Development for Basic and Clinical Cancer Research
Open
$5.1M pool
Early-Stage Innovative Technology Development for Basic and Clinical Cancer Research
Scheduled
$5.4M pool
HEAL Initiative: Translating Addiction Epidemiology, Prevention, Treatment, and Recovery Research into Practice
Open
- pool
BRAIN Initiative: Exploratory Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain
Open
$6M pool
Catalyze: Product Definition for Small Molecules, Biologics and Combination Products - Target Identification and Validation, and Preliminary Product/Lead Series Identification
Open
- pool
Catalyze Product Definition Medical Device prototype design/testing and disease target identification and assay development
Open
- pool
HEAL Initiative: Studies to Enable Analgesic Discovery
Open
- pool
INCLUDE Project: Clinical Trials Phased Awards for Down syndrome Research
Open
$3M pool
NIH Research Project Cooperative Agreement (U01)

Funds Research Project - Cooperative Agreements, NIH's U01 mechanism.

34 grants
NIDA Animal Genomics Program
Open
- pool
Limited Competition: Renewal of Existing NINDS-Supported Clinical Trial Cooperative Agreement Awards
Open
- pool
First in Human and Early Stage Clinical Trials of Novel Investigational Drugs or Neuromodulatory Device-based Interventions for Psychiatric Disorders
Open
- pool
Utilizing the PLCO Biospecimens Resource to Bridge Gaps in Cancer Etiology and Early Detection Research
Open
- pool
Integrating Biospecimen Science Approaches into Clinical Assay Development
Open
- pool
Translational Efforts to Advance Gene-based Therapies for Ultra-Rare Neurological and Neuromuscular Disorders
Open
- pool
NIDCD Cooperative Agreement for Clinical Trials in Communication Disorders
Open
- pool
National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders (U01)
Open
- pool
Opportunities for Collaborative Research at the NIH Clinical Center
Open
- pool
Expanding the Therapeutic Pipeline for Treating and Preventing Alzheimer's Disease and Related Dementias: Preclinical Validation and Drug Discovery for Novel Candidate Targets
Between cycles
- pool
The Metastasis Research Network (MetNet): MetNet Research Projects
Open
- pool
Causal Hypotheses on the Oral-Systemic Health Impacts of Human Behaviors among People with Chronic Conditions
Open
- pool
NIDCR Prospective Observational or Biomarker Validation Study Cooperative Agreement
Open
- pool
NIAID Clinical Trial Implementation Cooperative Agreement
Open
- pool
Research Opportunities in Cancer Epidemiology Cohort Studies
Open
- pool
Opportunities for Collaborative Research with the NIH Intramural Research Program
Scheduled
- pool
Alzheimer's Drug-Development Program
Scheduled
- pool
Canine Cancer Immunotherapy Network (K9CIN)
Scheduled
- pool
Early-Stage Development of Informatics Technologies for Cancer Research and Management
Open
$2.4M pool
Cooperative Agreement for In Vivo High-Resolution Imaging for Inner Ear Visualization
Closed
$500K pool
Community Engagement Evaluation and Data Coordination (CEED) Hub to Advance Data and Practice Transformation for Optimizing Oral Health for All
Open
$1M pool
Continuation of the Collaborative Islet Transplantation Registry
Closed
$700K pool
Continuation of the Cardiovascular Repository for-Type 1 Diabetes (CARE-T1D) Consortium U01 (Open Competition)- Research
Open
$6M pool
Optimal Treatment Strategies for use of Anti-Obesity Medications (AOMs) in Children and Adolescents Clinical Centers
Open
$3M pool
Multimodal AI to Accelerate Precision Medicine for Type 1 Diabetes
Scheduled
$5M pool
GREGoRi Data Coordination and Outreach Center
Open
$2M pool
GREGoRi Technology Integration Center
Open
$3M pool
GREGoRi Innovation Projects
Open
$7.5M pool
ancient DNA for Modern Genomics (aDMG) Research Projects
Scheduled
- pool
BRAIN Initiative: Brain Behavior Quantification and Synchronization- Next Generation Sensor Technology Development
Open
- pool
Amyotrophic Lateral Sclerosis (ALS) Intermediate Patient Population Expanded Access
Open
$40M pool
Genomic and Biologic Therapies for ADRD
Between cycles
$6M pool
BRAIN Initiative Connectivity across Scales (BRAIN CONNECTS): Specialized Projects for Scalable Technologies
Open
$10M pool
Development and Testing of a Multi-use Frameworks Playbook for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI)
Open
$2M pool
NIH Resource-Related Research Projects Cooperative Agreement (U24)

Funds Resource-Related Research Projects - Cooperative Agreements, NIH's U24 mechanism.

14 grants
NIH Phase 1 Exploratory/Developmental Cooperative Agreement (UG3)

Funds Phase 1 Exploratory/Developmental Cooperative Agreement, NIH's UG3 mechanism.

18 grants
Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of the Nervous System
Open
- pool
NIH StrokeNet Clinical Trials and Biomarker Studies for Stroke Treatment, Recovery, and Prevention
Open
- pool
NIDCR Drug, Biologic, Device and/or Procedure Intervention Clinical Trial Planning and Implementation Cooperative Agreement
Open
- pool
NIAMS Clinical Trial Implementation Cooperative Agreement (UG3/UH3)
Open
- pool
NIDCR Behavioral and Social Intervention Clinical Trial Planning and Implementation Cooperative Agreement
Open
- pool
Seamless Early-Stage Clinical Drug Development (Phase 1 to 2a) for Novel therapeutic Agents for the Spectrum of Alzheimer's Disease (AD) and AD-related Dementias (ADRD)
Open
- pool
Limited Competition: Clinical and Translational Science Award (CTSA) Program: Collaborative and Innovative Acceleration Award
Open
$650K pool
Leveraging Network Infrastructure to Conduct Innovative Research for Women, Children, Pregnant and Lactating Women, and Persons with Disabilities
Open
- pool
Blueprint MedTech Translator
Open
- pool
Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose
Open
- pool
Clinical Trials and Ancillary Studies Conducted within NIH-Funded Clinical Trial Research Networks
Scheduled
- pool
Clinical Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials
Open
- pool
Community-Based Participatory Research to Advance Data and Practice Transformation (ADAPT) for Optimizing Oral Health for All
Open
- pool
Multi-Site Investigator-Initiated Clinical Trials
Scheduled
- pool
BRAIN Initiative: Next-Generation Devices for Recording and Modulation in the Human Central Nervous System
Between cycles
- pool
HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain
Open
$11M pool
PRIMED-AI: Data-to-Model Academic-Industrial Partnerships (D2M-AIP) for Precision Medicine with AI: Integrating Imaging with Multimodal Data
Open
- pool
Model-to-Clinic (M2C) for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI)
Open
- pool
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