Complement-ARIE — Open Funding (Seed)
Supports development of human-based new approach methodologies replacing animal models in relevant research.
Complement-ARIE (Complement Animal Research In Experimentation) is an NIH Common Fund program approved by the NIH Council of Councils on January 25, 2024. Its mission is to accelerate the development, standardization, validation, and deployment of human-based New Approach Methodologies (NAMs) — laboratory and computational approaches intended to more accurately model human biology and to complemen…
Funds development, standardization, validation, and deployment of human-based New Approach Methodologies (NAMs) intended to complement or replace animal models in biomedical and drug research.
Sign up free to see the funding breakdown
Sign up free to see the industries in scope
Sign up free to see the full eligibility
Sign up free to see the timeline
Guides for this application
All guides →NIH Biosketch Guide: Format, SciENcv Steps, and Examples
Learn what an NIH biosketch is, how the format works, what to prepare for SciENcv, and how startup teams should avoid common biosketch mistakes.
Write proposalHow to Write a Specific Aims Page
Learn how to write a specific aims page for NIH, SBIR-adjacent, and translational R&D grants, with structure, reviewer logic, examples, and common mistakes.
Where to applyGrants for Biotech Startups: NIH, NSF, SBIR/STTR, and Non-Dilutive Funding
A practical guide to grants for biotech startups, including NIH SBIR/STTR, NSF, translational funding, evidence, regulatory readiness, and budgets.
Submit & reportSAM.gov Registration and UEI Guide for Federal Grant Applicants
Learn how SAM.gov registration, UEI numbers, Grants.gov accounts, organization profiles, workspace roles, and renewal timing fit together.
More from NIH Common Fund
All grants from this funder →CARE for Health — Open Funding (Seed)
🇺🇸NIH Common Fund · United States
Supports integrating clinical research into primary care environments through rural-focused network models.
Human Virome Program — Open Funding (Seed)
🇺🇸NIH Common Fund · United States
Offers exploration of the healthy human virome and virus host interactions across translational studies.
NIH Common Fund Venture Program — Open Funding (Seed)
🇺🇸NIH Common Fund · United States
Supports high-potential short- to medium-range initiatives that can seed major breakthroughs.
Replication Initiative — Open Funding (Seed)
🇺🇸NIH Common Fund · United States
Funds independent validation of biomedical findings to strengthen reproducibility in research.
NIH Director's Early Independence Award
🇺🇸NIH Common Fund · United States
Funds a scientist to skip the postdoc entirely and run their own lab straight after the doctorate — ten awards of $350,000 each.
NIH Director's New Innovator Award
🇺🇸NIH Common Fund · United States
Supports early-stage researchers with transformative ideas in high-risk biomedical studies.
Similar grants
Browse the directory →
ASPIRE Reduction-to-Practice (Seed)
🇺🇸NCATS · United States
Supports translational chemistry and automation platform development through university-linked partnerships.
ARPA-H SBIR/STTR
🇺🇸ARPA-H · United States
Funds United States small businesses bridging health and neuroscience technologies from feasibility into advanced development.
ARPA-H Mission Office ISOs
🇺🇸ARPA-H · United States
Supports United States mission teams with boundary-pushing health initiatives beyond existing programme limits.
ARPA-H Initiatives & Sprints
🇺🇸ARPA-H · United States
Runs fast-turnaround health technology opportunities in United States for high-potential exploratory science and engineering.
Assay Validation of High Quality Markers for Clinical Studies in Cancer
🇺🇸NIH · United States
Funds two years of analytical validation then three of clinical validation for a cancer biomarker assay that already works on human samples.
ARPA-H Program ISOs (topic-specific)
🇺🇸ARPA-H · United States
Funds United States health initiatives through topic-focused pathways across multiple mission areas and agencies.