National Institutes of Health logo
NIH SBIR

NIH SBIR Direct-to-Phase II (Omnibus)

Funds United States small businesses moving directly into major development when early biomedical feasibility is already established.

OpenNational Institutes of HealthUnited States

The NIH SBIR Direct-to-Phase II (D2PII) Omnibus allows U.S. small businesses to apply directly for Phase II-level funding without a prior NIH Phase I award, provided the company can demonstrate that Phase I-equivalent feasibility has already been established through other means. Issued under activity code R44 as a "New" application (not a renewal), D2PII awards carry the same cap as standard Phase…

Phase II-scope biomedical R&D for projects whose feasibility has been established through prior non-SBIR work (e.g. university research, foundation funding, internal R&D).

CycleiHow often this grant runs — e.g. annually, on a rolling basis, or a one-off call.Multiple per year
Next deadlineiThe next date applications are due. Rolling means you can apply any time.5 Sept 2026
Decision timeiTypical time from the deadline to the funder's decision.36 weeks
Project durationiHow long the funded work is expected to run.1–24 months
Award typeiThe form of funding — grant, equity, loan, tax credit, etc.Grant
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.0%
Funding pooliThe total budget available across all awards in this round.$80M

Sign up free to see the funding breakdown

Sign up free to see the industries in scope

Sign up free to see the full eligibility

Sign up free to see how to apply

Sign up free to see what you submit

Sign up free to see how they score you

Sign up free to see the timeline

Sign up free to see where teams trip up

Last verified: 22 Jul 2026Source: grants.nih.gov