NIH SBIR Phase I (Omnibus)
Funds United States small businesses advancing biomedical and behavioral-health innovations through early technical validation.
The NIH SBIR Phase I Omnibus is the National Institutes of Health's flagship non-dilutive feasibility grant for U.S. small businesses working on biomedical, behavioral-health, or health-services innovation. Issued under activity code R43, Phase I awards are capped at $306,872 in total costs (direct costs, indirect costs, and a permitted profit fee of up to 7%) and are intended to fund six to twelv…
Any biomedical, behavioral, or health-services R&D aligned to the mission of one of NIH's 27 institutes and centers. Topic priorities are published by each IC; the omnibus parent NOFO is investigator-initiated within those priorities.
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Guides for this application
All guides →SBIR/STTR Grants for Deeptech Startups
A practical guide to SBIR and STTR grants for deeptech startups, including agency fit, Phase I and II logic, eligibility, budgets, and review criteria.
DocumentsNIH Biosketch Guide: Format, SciENcv Steps, and Examples
Learn what an NIH biosketch is, how the format works, what to prepare for SciENcv, and how startup teams should avoid common biosketch mistakes.
Write proposalHow to Write a Specific Aims Page
Learn how to write a specific aims page for NIH, SBIR-adjacent, and translational R&D grants, with structure, reviewer logic, examples, and common mistakes.
Where to applyGrants for Biotech Startups: NIH, NSF, SBIR/STTR, and Non-Dilutive Funding
A practical guide to grants for biotech startups, including NIH SBIR/STTR, NSF, translational funding, evidence, regulatory readiness, and budgets.
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🇺🇸NIH · United States
Funds the design and early validation of frameworks — guidelines, protocols and standard procedures — for building and deploying multimodal medical AI reliably.
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Funds a clinical centre inside a consortium testing how to use anti-obesity medication in children without harming their growth or mental health.
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Funds the single centre that runs statistics, data and coordination for the consortium testing anti-obesity medication in children.
Addressing Methodological Challenges with Clinical Trials of Rapid-Acting Psychotropic Interventional Drugs (RAPIDs)
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Funds work on the methodological problems that make trials of rapid-acting psychotropic drugs hard to interpret, and on sustaining the treatment afterwards.
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Funds two years of analytical validation then three of clinical validation for a cancer biomarker assay that already works on human samples.
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🇺🇸NIH · United States
Funds the clinical validation of a cancer biomarker assay whose analytical performance has already been proven.
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