CPRIT Prevention

CPRIT Prevention — Primary Prevention of Cancer

Funds Texas primary prevention projects reducing cancer risk through layered interventions and outreach.

Eligibility · United States · US-TX

⚠ This may reflect a past cycle — verify the current call on the funder's site.

The Cancer Prevention and Research Institute of Texas (CPRIT) Primary Prevention of Cancer RFA (P-271-PPC) funds multi-level interventions targeting behavioral, environmental, and systemic cancer risk factors in Texas priority populations. Funded topic areas include tobacco cessation, obesity, physical inactivity, unhealthy diet, alcohol use, sun exposure, HPV vaccination, hepatitis B vaccination, and environmental and occupational cancer exposures. Projects must operate at multiple levels simultaneously — individual, community, and system — rather than single-channel behavioral programs. Maximum funding is $1 million over five years for new projects and $2.5 million over five years for expansion projects that scale existing programs.

Eligible applicants include Texas nonprofits, universities, and research institutions; for-profit companies and individuals are excluded. The FY2027 Cycle 1 cycle opened for applications on March 18, 2026 and closes June 10, 2026. Award notifications are issued in November 2026. All applications are submitted through cpritgrants.org, which requires an organizational account and institutional signatory. Funding is drawn from CPRIT's prevention allocation, which represents 10% of total CPRIT annual appropriations; CPRIT's prevention portfolio has contributed to a documented 14% decline in Texas cancer mortality from 2010 to 2018.

Review is conducted by CPRIT's Prevention Review Council — panels of 12 to 15 external reviewers who live and work outside Texas. After initial scoring and panel discussion, the Prevention Review Council forwards recommendations to the Program Integration Committee, whose CEO-led composition includes the Chief Prevention Officer and Commissioner of State Health Services. Final award authority rests with the CPRIT Oversight Committee, which requires a two-thirds majority vote. CPRIT's independent economic analysis estimates each dollar spent on prevention generates $29.08 in downstream savings.