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Program

ARPA-H PROVE-IT Networks

Funds United States proof of concept health networks testing ideas before broader clinical and public impact.

Advanced Research Projects Agency for HealthUnited StatesGrant

ARPA-H PROVE-IT Networks sits under the US Advanced Research Projects Agency for Health and focuses on health system implementation, especially trial and network models that can move into practice. The name fits a program that is less about first principles and more about getting evidence into real-world delivery. It is a narrower ARPA-H line with a clear operational brief. The grant range runs from $1 million to $10 million, with a median award of $3 million. It runs annually, is open to US-based for-profit applicants, excludes nonprofits and individuals, and targets TRL 4 to 7. The route also bars stacking the same scope, so the application has to stand on its own. The strongest applicants will have a credible implementation network, a defined trial or rollout model, and a clear reason the work belongs in a health-system setting rather than a generic research program. The route rewards teams that can show how an intervention will be tested, adopted, and sustained. For applicants with that shape of proposal, PROVE-IT Networks is the ARPA-H line built for operational proof.

Max award$10M
Realistic median$3M
Success rate10–20%
Decision time—

No upcoming rounds verified. Cadence: Annual.

Last verified: 11 May 2026Source: arpa-h.gov