Advanced Research Projects Agency for Health

Funds ARPA-H, the United States health mission accelerating high-impact biomedical advances for major diseases.

The Advanced Research Projects Agency for Health (ARPA-H) was established in March 2022 with a $1 billion founding appropriation, and has run at approximately $1.5 billion annually since FY2023. Its mission is to support transformative biomedical and health research — explicitly outside the traditional NIH peer-review model — using DARPA-style program-manager-driven solicitations.

ARPA-H is organized around four Mission Offices: - Health Science Futures — research that removes scientific and technological limitations to the health care of the future - Proactive Health — preventative programs that reduce the likelihood that people become patients - Resilient Systems — robust and integrated health care systems - Scalable Solutions — challenges of geography, distribution, manufacturing, data, and economics in delivering equitable health solutions

Across these Mission Offices, ARPA-H has launched 23 individual programs as of 2026. The agency awards funding via cooperative agreements, Other Transactions (OTs), and procurement contracts — not pure grants. Mission Office ISOs are open year-round on a rolling basis; specific Program and Initiative ISOs are time-limited.