ARPA-H Resilient Systems / Health Science Futures

ARPA-H Resilient Systems / Health Science Futures sits under the US Advanced Research Projects Agency for Health and backs biomedical resilience work inside the wider ARPA-H portfolio. The notes place that broader portfolio at more than $300 million a year across program areas, which makes this one part of a substantial federal health-innovation stack. Its remit is narrower than the parent agency's full span, but it sits in the same high-risk, high-ambition lane. The grant range runs from $500,000 to $40 million, with a median award of $5 million. It runs annually, is open to US-based for-profit applicants and nonprofits, and excludes individuals. The technical screen starts at TRL 3 and reaches TRL 7, so the route is meant for work beyond the lab concept stage but still before full commercialization. The fit is strongest for teams that can frame a resilience problem in health systems terms and show enough technical maturity to justify a larger award. Applicants also need to avoid trying to layer this on top of the same scope elsewhere, because the route does not allow stacking on the same project. For teams with a credible transition plan, this is the part of ARPA-H where system change matters more than a single product claim.

No upcoming rounds verified. Cadence: Annual.