Research Funding Opportunities (Topic RFAs)
Offers Topic-specific solicited research calls addressing critical Type Diabetes gaps.
Breakthrough T1D issues topic-specific Request for Applications (RFAs) across its five priority research areas throughout the fiscal year. Each RFA targets a defined scientific gap — recent examples include cell therapy vascularization, continuous ketone monitoring, immune tolerance in islet replacement, and organ-on-a-chip disease modeling. Most RFAs use a two-stage LOI + full proposal process. LOI deadlines are typically at 5:00pm ET. Submission portal for all RFAs is https://breakthrought1d.smartsimple.us/.
Each grant below is a distinct funding opportunity with its own eligibility, scope, and deliverables.
Supports studies on common autoimmune mechanisms to inform shared treatment strategies for type 1 diabetes and related conditions.
Funds type 1 diabetes research to improve immune tolerance pathways for safer islet-based replacement approaches.
Supports in vitro disease modeling for type 1 diabetes using chip-based systems and translational experimental platforms.
Funds translational methods to define, monitor, and improve vascularization in islet-based diabetes therapies.