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NIH Common Fund

Complement-ARIE Challenge

Pays up to $50,000 each to 20 teams building human-based alternatives to animal testing.

ClosedNIH Common FundUnited StatesApplicants in Indiana

The Complement-ARIE Challenge is an NIH Common Fund prize that pays up to $50,000 each to 20 teams building human-based alternatives to animal testing. Teams submitted a 15-page whitepaper covering methodology, team expertise, scientific rationale and potential impact, scored against five weighted judging criteria: understanding of the problem, feasibility, innovation, potential impact and team coโ€ฆ

The challenge sought New Approach Methodologies (NAMs) that model human biology without animal models: in vitro human-derived cell or tissue systems, in silico computational and AI-driven simulations, in chemico cell-free systems, and integrations across these. Submissions had to demonstrate substantial advancement over current NAM approaches and could target areas like rare disease, pregnancy, toxicology or drug response modeling.

CycleiHow often this grant runs - e.g. annually, on a rolling basis, or a one-off call.No fixed schedule
Next deadlineiThe next date applications are due. Rolling means you can apply any time.-
Decision timeiTypical time from the deadline to the funder's decision.-
Project durationiHow long the funded work is expected to run.-
Award typeiThe form of funding - grant, equity, loan, tax credit, etc.Prize
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.-
Funding pooliThe total budget available across all awards in this round.$1M

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