The Genesis Mission: AI for Science and Energy
Provides research teams and institutions for The Genesis Mission: AI for Science and Energy in artificial intelligence, energy systems, and quantum systems.
The Genesis Mission: Transforming Science and Energy with AI (FOA DE-FOA-0003612) is the DOE Office of Science's flagship FY2026 cross-cutting artificial intelligence initiative. Posted March 17, 2026 and last updated April 20, 2026, the solicitation covers AI applied to all five major SC program areas — ASCR, BES, BER, FES, and HEP — making it the broadest AI-for-science grant in the FY2026 federal portfolio. The final close date is December 17, 2026 at 11:59 p.m. Eastern. Eligible institution types include universities, national laboratories, industry, and nonprofits. Award amounts are specified in the FOA PDF and were not published in web-accessible sources.
The solicitation uses a three-window phased structure. Phase I applications were due May 1, 2026 at 11:59 p.m. ET via Grants.gov. Phase II Letters of Intent were due May 1, 2026 at 5:00 p.m. ET via PAMS, and Phase II full applications were due May 19, 2026 at 11:59 p.m. ET via Grants.gov. The third window — Phase II applications from Phase I awardees — closes December 17, 2026, the same as the FOA's final close date. Applications are submitted through Grants.gov; LOIs and pre-applications through PAMS at pamspublic.science.energy.gov. Because Phase I and the initial Phase II window have closed, prospective new applicants must verify current eligibility with the relevant SC program office.
The Genesis Mission is ASCR-led but cross-office, and teams should identify which SC program office's research priorities their AI work advances, as each office maintains distinct review panels. Competitive proposals will demonstrate technically rigorous AI methodologies, a clear connection to DOE scientific or energy mission areas, and a qualified multi-investigator team. The PAMS helpdesk is sc.pams-helpdesk@science.doe.gov or (855) 818-1846. Budget details, page limits, and the full review criteria are in the FOA PDF available at energy.gov/grants/pdf/foas/2026/DE-FOA-0003612-000003.pdf.
Artificial intelligence applied to DOE Office of Science mission areas, including ASCR, BES, BER, FES, and HEP research programs, under a phased multi-deadline FOA closing December 2026.
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