The Genesis Mission: Transforming Science and Energy with AI
Supports AI for science progress from early concept stages toward national-scale implementation.
The Genesis Mission: Transforming Science and Energy with AI (DE-FOA-0003612) is the DOE Office of Science's flagship artificial intelligence initiative for FY2026, covering AI applications across all five primary program offices: Advanced Scientific Computing Research (ASCR), Basic Energy Sciences (BES), Biological and Environmental Research (BER), Fusion Energy Sciences (FES), and High Energy Physics (HEP). The FOA was posted March 17, 2026, last updated April 20, 2026, and carries a final close date of December 17, 2026. The competition is structured in two phases plus a downstream track: Phase I applications closed May 1, 2026; Phase II applications closed May 19, 2026; the remaining open window — Phase II from Phase I Awards — accepts applications through December 17, 2026, at 11:59 PM Eastern.
Eligible applicants include universities, national laboratories, for-profit companies, nonprofits, and other research organizations based in the United States; individuals are not eligible. No minimum or maximum TRL is specified in the available sources, consistent with the cross-cutting nature of an AI-for-science program spanning both fundamental and applied research. Pre-applications and letters of intent are submitted via the PAMS portal at pamspublic.science.energy.gov; full applications are submitted via Grants.gov. Exact award sizes and periods of performance are specified in the FOA PDF (DE-FOA-0003612) rather than the indexed HTML sources.
For organizations pursuing the remaining December 17, 2026 window, eligibility is limited to Phase II applicants whose Phase I submissions resulted in formal awards — this is not an open public window for first-time applicants. Teams building AI tools, foundation models, or scientific computing infrastructure for energy or science applications that did not submit in Phases I or II should monitor the FES, BES, and ASCR program-office funding pages for any follow-on Genesis Mission solicitations or related FOAs expected in early FY2027.
Artificial intelligence applied to scientific discovery and energy research across DOE Office of Science program offices including ASCR, BES, BER, FES, and HEP.
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