NIH STTR Phase II (Omnibus)
Funds United States small-business and research-partner teams advancing biomedical projects already proven in early studies.
The NIH STTR Phase II Omnibus funds the full R&D execution phase of a technology that has cleared STTR Phase I feasibility review, issued under activity code R42 with the same $2,045,816 total-cost cap and one-to-three-year performance period as its SBIR Phase II counterpart. NIH disburses approximately $65 million per fiscal year in STTR Phase II awards. The program continues the formal collabora…
Continuation of a successful STTR Phase I project, with continued formal collaboration between the small business and the non-profit research-institution partner.
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Guides for this application
All guides →SBIR/STTR Grants for Deeptech Startups
A practical guide to SBIR and STTR grants for deeptech startups, including agency fit, Phase I and II logic, eligibility, budgets, and review criteria.
DocumentsNIH Biosketch Guide: Format, SciENcv Steps, and Examples
Learn what an NIH biosketch is, how the format works, what to prepare for SciENcv, and how startup teams should avoid common biosketch mistakes.
Write proposalHow to Write a Specific Aims Page
Learn how to write a specific aims page for NIH, SBIR-adjacent, and translational R&D grants, with structure, reviewer logic, examples, and common mistakes.
Where to applyGrants for Biotech Startups: NIH, NSF, SBIR/STTR, and Non-Dilutive Funding
A practical guide to grants for biotech startups, including NIH SBIR/STTR, NSF, translational funding, evidence, regulatory readiness, and budgets.
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Backs small businesses scaling proven translational findings into applied solutions and early market readiness.