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National Institutes of Health

NIH Research Project Grant

Funds a defined research project that includes at least one clinical trial, through the permanently open NIH research project announcement.

The same standing door as the main research project announcement, for projects that put at least one clinical trial inside them.

The mechanism supports a discrete, specified, circumscribed project in an area representing the investigator's own interests and competencies. What differs here is a requirement rather than a permission: at least one clinical trial must be proposed.

Fit is judged the s

Discrete, specified, circumscribed research projects including at least one clinical trial, in areas representing the investigator's own interests and competencies, relating to the programmatic interests of one or more participating National Institutes of Health institutes and centres. A clinical trial is required.

CycleiHow often this grant runs — e.g. annually, on a rolling basis, or a one-off call.Multiple per year
Next deadlineiThe next date applications are due. Rolling means you can apply any time.7 Jan 2028
Decision timeiTypical time from the deadline to the funder's decision.26 weeks
Project durationiHow long the funded work is expected to run.
Award typeiThe form of funding — grant, equity, loan, tax credit, etc.Grant
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.
Funding pooliThe total budget available across all awards in this round.

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Last verified: 25 Aug 2026Funder reference: PA-25-305Source: www.grants.gov