NIH Research Project Grant

The NIH Research Project Grant (R01) is NIH's standard investigator-initiated grant and the main cross-IC route for independent research programs. Two parent NOFOs are active, one that allows clinical trials and one that does not, and both remain open through January 8, 2028. It is a grant mechanism with three application cycles per year, using the standard February, June, and October due dates for new applications. The umbrella record accepts U.S.-based for-profit, nonprofit, university, and research-organization applicants, while individuals are not eligible. The parent announcements page treats R01 as the broad umbrella for investigator-initiated work across the institute system, with the same activity code carrying both renewal and resubmission paths. The R01 fits established projects that can stand on a strong scientific case and survive peer review through CSR and the awarding IC. Topic-specific R01s live under the relevant institute, but this parent record is the broad entry point for independent NIH research funding.

Each grant below is a distinct funding opportunity with its own eligibility, scope, and deliverables.