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NIH Research Project Grant

Natural History of Disorders Screenable in the Newborn Period

Funds studies of how conditions found by newborn screening unfold — the sequence and timing of symptoms, and what changes the course.

A newborn screening programme finds a condition before anybody is ill. What happens next depends on knowing how that condition normally unfolds, and for many screened conditions nobody does.

This notice funds building that knowledge, for disorders that are currently part of statewide newborn screening programmes or may become part of them.

The core of it is the sequence and timing of symptom dev

Studies expanding knowledge of the natural history of disorders that are or may become part of statewide newborn screening programmes, characterising the sequence and timing of symptom development, establishing genotype-phenotype correlations where possible, and identifying modifying genetic, epigenetic or environmental factors, to support targeted age-appropriate treatments, baselines for evaluating interventions, mechanism identification and diagnostic accuracy. Clinical trials are optional.

CycleiHow often this grant runs — e.g. annually, on a rolling basis, or a one-off call.Multiple per year
Next deadlineiThe next date applications are due. Rolling means you can apply any time.7 Jan 2028
Decision timeiTypical time from the deadline to the funder's decision.26 weeks
Project durationiHow long the funded work is expected to run.
Award typeiThe form of funding — grant, equity, loan, tax credit, etc.Grant
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.
Funding pooliThe total budget available across all awards in this round.

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Last verified: 25 Aug 2026Funder reference: PAR-25-227Source: www.grants.gov