ARPA-H

ARPA-H sits under the Advanced Research Projects Agency for Health and funds transformational biomedical and health R&D that standard peer review often misses. The agency runs a large U.S. portfolio built around Mission Office open solicitations, topic-specific program calls, initiatives and sprints, and SBIR/STTR routes. Its funding methods include cooperative agreements, Other Transactions, and procurement contracts, with awards in the source material ranging from $150,000 to $80 million and a median actual award of $8 million. Eligibility is broad for a federal health agency: for-profit companies, nonprofits, and individuals can all apply, U.S. operations are required, and projects span roughly TRL 2 to 7. The rules also limit applicants to no more than three concurrent ARPA-H prime awards across its mechanisms. ARPA-H is built for upstream health technologies that still need real R&D before they can become clinical products. The strongest fit is a project that maps cleanly to a mission area, shows technical depth, and is not limited to clinical trials of already developed products. Applicants do best when they can connect a high-risk idea to a clear mission outcome and a credible path to execution.

Each grant below is a distinct funding opportunity with its own eligibility, scope, and deliverables.