DOE Genesis Mission — AI Science & Energy Challenges

DOE Genesis Mission sits under the U.S. Department of Energy as a national initiative led by Under Secretary for Science Darío Gil, with the White House Office of Science and Technology Policy and DOE's 17 national laboratories in the operating frame. It is built to double the productivity and impact of American research within a decade by linking AI systems, supercomputers, experimental facilities, and datasets across discovery science, national security, and energy innovation. The main funding vehicle is DE-FOA-0003612, a $293 million opportunity released in March 2026. Phase I supports nine-month projects with awards of $500,000 to $750,000, while Phase II supports three-year projects with awards of $6 million to $15 million. Teams may apply directly to either phase in FY2026, and eligible applicants include DOE national laboratories, U.S. industry, and academia. The program is strongest for interdisciplinary teams that can work through DOE infrastructure and deliver on one of the 26 named challenge areas, including advanced manufacturing, biotechnology, critical materials, nuclear energy, and quantum information science. Initial industry partners include NVIDIA, OpenAI for Government, IBM, Microsoft, AMD, AWS, Google, and Oracle, which gives the initiative unusual scale for a federal research platform.

Each grant below is a distinct funding opportunity with its own eligibility, scope, and deliverables.