Horizon Cancer: Pragmatic Immunotherapy Trials
Funds three pragmatic clinical trials, €7-8M each, testing existing cancer immunotherapies in real-world care for patients whose disease resists treatment.
Cancer patients whose disease doesn't respond to standard treatment — refractory cancer, at any stage, any subtype, any age — need better access to immunotherapy that's actually tailored to them. Immunotherapy research has produced real treatment options, but Europe's oncology systems are fragmented, costs are rising, and a lot of that promise doesn't reach routine care in a way that's affordable …
Running randomised or cluster-randomised, academic investigator-initiated pragmatic clinical trials that test immunotherapeutic interventions for patients with refractory cancers — any subtype, any stage, any age group — to find out what works best in real-world care, not just under ideal trial conditions. Primary and secondary endpoints (overall survival, patient-reported outcomes, quality of life) have to be defined together with patients and caregivers, and results have to be broken down by sex, gender, age and factors like socio-economic status or ethnicity. Biomarker-informed patient stratification and analysis of the trial's own data are the only translational research in scope — there's no separate track for developing new therapeutics, biomarkers or diagnostics. The consortium has to bring a genuine mix of disciplines and sectors, including regional or national health authorities as partners, and successful projects join the EU Cancer Mission's 'Diagnosis and Treatment' project cluster.
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