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MassChallenge

MassChallenge Healthcare Challenge Program

Supports healthcare and life science startups to strengthen partnerships and scaling through a MassChallenge industry track.

ClosedMassChallengeUnited States

MassChallenge is a Boston-based, globally operating nonprofit accelerator founded in 2009. Its Healthcare Challenge Program is one of several industry-specific challenge tracks that match mid-to-late-stage startups with corporate partners seeking validated solutions. The 2026 cycle ran January through May 2026 across a four-month program structure; applications closed November 5, 2025. Corporate cโ€ฆ

Healthcare and life sciences startups with validated products/solutions ready for corporate scaling partnerships.

CycleiHow often this grant runs - e.g. annually, on a rolling basis, or a one-off call.Annual
Next deadlineiThe next date applications are due. Rolling means you can apply any time.-
Decision timeiTypical time from the deadline to the funder's decision.-
Project durationiHow long the funded work is expected to run.4 months
Award typeiThe form of funding - grant, equity, loan, tax credit, etc.Prize
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.0%
Funding pooliThe total budget available across all awards in this round.-

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Guides for this application

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Open

MassChallenge Israel (Seed)

๐Ÿ‡ฎ๐Ÿ‡ฑMassChallenge ยท United States

Supports Israeli startups with no-equity acceleration, corporate engagement, and international venture exposure through MassChallenge Israel.

AIMedtech+2
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Between cycles

MassChallenge Healthcare & Life Sciences Traction Program

๐Ÿ‡บ๐Ÿ‡ธMassChallenge ยท United States

Runs MassChallenge Healthcare and Life Sciences Traction for early-stage founders with equity-free validation, mentoring, and investor readiness.

MedtechBiotech
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Between cycles

MassChallenge Security & Resiliency Traction Program

๐Ÿ‡บ๐Ÿ‡ธMassChallenge ยท United States

Runs MassChallenge Security and Resiliency Traction for early cyber, infrastructure, and defense-adjacent founders with scale preparation.

CybersecurityDefense+1
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Between cycles

MassChallenge Switzerland

๐Ÿ‡จ๐Ÿ‡ญMassChallenge ยท United States

Supports Swiss agtech, industrial, and health startups through a MassChallenge program with mentorship, networking, and investment pathways.

AgritechFood Tech+4
$1M
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Closed

MassChallenge FinTech Challenge Program

๐Ÿ‡บ๐Ÿ‡ธMassChallenge ยท United States

Supports fintech startups with proven products through MassChallenge's program for modern financial services, payments, and regtech pilots.

AICybersecurity
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Closed

Security & Resiliency Traction Program

MassChallenge ยท United States

Runs a 10-week, no-cost, non-dilutive accelerator for early-stage security, resiliency, and dual-use founders, from Pre-Seed through Series A+, culminating in enterprise pilots and investor-ready pitches.

DefenseRobotics+4
NIH Office of Autoimmune Disease Research, Office of Research on Women's Health (OADR-ORWH) logo
Open

NOURISH: Autoimmunity Digital Health Challenge

๐Ÿ‡บ๐Ÿ‡ธOADR-ORWH ยท United States

Awards up to $650,000 across three phases for digital tools tracking autoimmune nutrition.

MedtechBiotech
$100KJan'27
Massachusetts Institute of Technology logo
Open

MIT Solve Global Challenges

๐Ÿ‡บ๐Ÿ‡ธMIT ยท United States

Supports teams tackling global challenges by selecting and backing scalable ideas through MIT Solve challenge pathways.

AIBiotech+3
$10K โ€“ $150KNov'26
National Institutes of Health logo
Open

TRDNT Challenge Phase II: Prototype Development and Use Case Demonstration

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Pays up to $120,000 per Interim Milestone winner and up to $320,000 per Final Submission winner to US-based researchers, startups and institutions that build a working prototype technology able to target endogenous RNA in human disease.

BiotechMedtech
$120K โ€“ $320KFeb'27
National Center for Advancing Translational Sciences logo
Open

Oligonucleotide Toxicity (OligoTox) Open Data Challenge

๐Ÿ‡บ๐Ÿ‡ธNCATS ยท United States

Pays cash prizes for public datasets that help predict oligonucleotide drug toxicity in human cells.

BiotechMedtech
$100KDec'26
National Institutes of Health logo
Open

Targeting RNA in Disease with Novel Technologies (TRDNT) Challenge

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Awards up to $13.1 million across three phases to US-based teams developing novel technologies that target RNA to treat human disease.

BiotechMedtech
$525KFeb'27
NIH National Cancer Institute logo
Open

Childhood, Adolescent and Young Adult (AYA) Cancer Data Innovation Challenge โ€” Track 1

๐Ÿ‡บ๐Ÿ‡ธNCI ยท United States

Pays entities up to $566,665 across three milestones to add shovel-ready cancer data or tools to NCI's CCDI ecosystem.

BiotechMedtech+1
$567KNov'26