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National Institutes of Health

Targeting RNA in Disease with Novel Technologies (TRDNT) Challenge

Awards up to $13.1 million across three phases to US-based teams developing novel technologies that target RNA to treat human disease.

OpenNational Institutes of HealthUnited States

Every Phase II submission has to include a PADP -- a detailed document covering how the technology will actually be made available to the wider scientific community -- plus the preliminary recruitment of an external partner to help carry that dissemination out, looking past the prize itself and not just the underlying science. Submissions also need concrete metrics of success and efficacy in treat…

TRDNT is looking for novel technologies that target endogenous RNA to treat disease, not standard RNA-based therapeutics, but new tools that modulate RNA-protein interactions, target long non-coding RNAs, screen for RNA-targeting small molecules, or address aberrant RNA structures. It's open to academic researchers, biotech founders, startups of any size, non-profits, and university tech-transfer teams working on RNA-targeting approaches relevant across multiple diseases.

CycleiHow often this grant runs - e.g. annually, on a rolling basis, or a one-off call.No fixed schedule
Next deadlineiThe next date applications are due. Rolling means you can apply any time.1 Feb 2027
Decision timeiTypical time from the deadline to the funder's decision.-
Project durationiHow long the funded work is expected to run.-
Award typeiThe form of funding - grant, equity, loan, tax credit, etc.Prize
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.-
Funding pooliThe total budget available across all awards in this round.$13.1M

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