Targeting RNA in Disease with Novel Technologies (TRDNT) Challenge
Awards up to $13.1 million across three phases to US-based teams developing novel technologies that target RNA to treat human disease.
Every Phase II submission has to include a PADP -- a detailed document covering how the technology will actually be made available to the wider scientific community -- plus the preliminary recruitment of an external partner to help carry that dissemination out, looking past the prize itself and not just the underlying science. Submissions also need concrete metrics of success and efficacy in treat…
TRDNT is looking for novel technologies that target endogenous RNA to treat disease, not standard RNA-based therapeutics, but new tools that modulate RNA-protein interactions, target long non-coding RNAs, screen for RNA-targeting small molecules, or address aberrant RNA structures. It's open to academic researchers, biotech founders, startups of any size, non-profits, and university tech-transfer teams working on RNA-targeting approaches relevant across multiple diseases.
Sign up free to see the funding breakdown
Sign up free to see the industries in scope
Sign up free to see the full eligibility
Sign up free to see how to apply
Sign up free to see what you submit
Sign up free to see the timeline
Sign up free to see where teams trip up
Guides for this application
All guides →NIH Biosketch Guide: Format, SciENcv Steps, and Examples
Learn what an NIH biosketch is, how the format works, what to prepare for SciENcv, and how startup teams should avoid common biosketch mistakes.
Write proposalHow to Write a Specific Aims Page
Learn how to write a specific aims page for NIH, SBIR-adjacent, and translational R&D grants, with structure, reviewer logic, examples, and common mistakes.
Where to applyGrants for Biotech Startups: NIH, NSF, SBIR/STTR, and Non-Dilutive Funding
A practical guide to grants for biotech startups, including NIH SBIR/STTR, NSF, translational funding, evidence, regulatory readiness, and budgets.
DocumentsGrant Work Plan Template: Work Packages, Gantt, Milestones, and Risks
Use this grant work plan template to structure work packages, tasks, owners, deliverables, Gantt timing, dependencies, and risk registers.
More from NIH
All grants from this funder →Advanced Development of Informatics Technologies for Cancer Research and Management
NIH · United States
Funds the enhancement of a cancer informatics tool that has cleared prototyping, shows real promise, and has not yet been widely adopted.
Community Engagement Evaluation and Data Coordination (CEED) Hub to Advance Data and Practice Transformation for Optimizing Oral Health for All
🇺🇸NIH · United States
Funds a single hub that coordinates data, evaluation and operations for a consortium of community-based oral health research projects.
Limited Competition: Small Grant Program for the NCATS Clinical and Translational Science Award (CTSA) Program (R03)
🇺🇸NIH · United States
Funds one small self-contained project for a scholar already inside the Clinical and Translational Science Award network, on the way to a first full award.
Model-to-Clinic (M2C) for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI)
NIH · United States
Funds the move of an imaging-centred multimodal AI tool from a trained and tested prototype towards real clinical use, as regulated device software.
PRIMED-AI: Data-to-Model Academic-Industrial Partnerships (D2M-AIP) for Precision Medicine with AI: Integrating Imaging with Multimodal Data
NIH · United States
Funds a company and an academic team to build and test an imaging-centred multimodal AI decision tool, developed as software that is a medical device.
Sustained Support for Informatics Technologies for Cancer Research and Management
NIH · United States
Funds the running costs and continued relevance of a cancer informatics tool that researchers already depend on.
Similar grants
Browse the directory →Childhood, Adolescent and Young Adult (AYA) Cancer Data Innovation Challenge — Track 1
🇺🇸NCI · United States
Pays entities up to $566,665 across three milestones to add shovel-ready cancer data or tools to NCI's CCDI ecosystem.
NIH Quantum Sensing Technology Challenge
🇺🇸NCATS · United States
Awards up to $1.6 million across stages for quantum-enabled biomedical sensing devices.
Unlocking Urologic Oncology Innovation QuickFire Challenge
🇺🇸J&J Innovation · United States
Supports innovators designing bladder and prostate cancer therapies and surgical tools through a J&J urologic oncology challenge.
NIH Quantum Computing Challenge
🇺🇸NCATS · United States
Awards up to $1.3 million across stages for new quantum algorithms solving biomedical problems.
NOURISH: Autoimmunity Digital Health Challenge
🇺🇸OADR-ORWH · United States
Awards up to $650,000 across three phases for digital tools tracking autoimmune nutrition.
MIT Solve Global Challenges
🇺🇸MIT · United States
Supports teams tackling global challenges by selecting and backing scalable ideas through MIT Solve challenge pathways.