National Institutes of Health logo
National Institutes of Health

Targeting RNA in Disease with Novel Technologies (TRDNT) Challenge

Awards up to $13.1 million across three phases to US-based teams developing novel technologies that target RNA to treat human disease.

OpenNational Institutes of HealthUnited States

Every Phase II submission has to include a PADP -- a detailed document covering how the technology will actually be made available to the wider scientific community -- plus the preliminary recruitment of an external partner to help carry that dissemination out, looking past the prize itself and not just the underlying science. Submissions also need concrete metrics of success and efficacy in treatโ€ฆ

TRDNT is looking for novel technologies that target endogenous RNA to treat disease, not standard RNA-based therapeutics, but new tools that modulate RNA-protein interactions, target long non-coding RNAs, screen for RNA-targeting small molecules, or address aberrant RNA structures. It's open to academic researchers, biotech founders, startups of any size, non-profits, and university tech-transfer teams working on RNA-targeting approaches relevant across multiple diseases.

CycleiHow often this grant runs - e.g. annually, on a rolling basis, or a one-off call.No fixed schedule
Next deadlineiThe next date applications are due. Rolling means you can apply any time.1 Feb 2027
Decision timeiTypical time from the deadline to the funder's decision.-
Project durationiHow long the funded work is expected to run.-
Award typeiThe form of funding - grant, equity, loan, tax credit, etc.Prize
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.-
Funding pooliThe total budget available across all awards in this round.$13.1M

Sign up free to see the funding breakdown

Sign up free to see the industries in scope

Sign up free to see the full eligibility

Sign up free to see how to apply

Sign up free to see what you submit

Sign up free to see the timeline

Sign up free to see where teams trip up

Guides for this application

All guides โ†’
National Institutes of Health logo
Open

NCI Community Oncology Research Program (NCORP) Academic Community Sites

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Funds an academic centre leading a network of community hospitals to enrol patients into NCI cancer trials โ€” about 50 awards from $73 million.

Biotech
Sep'26
National Institutes of Health logo
Open

NCI Community Oncology Research Program (NCORP) Community Sites

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Funds community hospitals and oncology practices to enrol their own patients into NCI cancer trials โ€” about 50 awards from a $73 million pool.

Biotech
Sep'26
National Institutes of Health logo
Open

NCI Community Oncology Research Program (NCORP) Research Bases

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Funds the seven hubs that design, run and analyse NCI's community cancer trials โ€” and carry the regulatory and data load for every site in the network.

Biotech
Sep'26
National Institutes of Health logo
Open

Connecting the Community for Maternal Health 2.0 (CCMH 2.0)

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Awards a $3.1 million prize purse across four phases to help U.S. nonprofits and Tribes build the research capacity to lead maternal health research in maternity care deserts.

$10K โ€“ $350KSep'26
National Institutes of Health logo
Open

Atopic Dermatitis Research Network (ADRN)

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Funds centres doing clinical and translational research on eczema โ€” chronic skin inflammation and how the skin defends itself. Four awards from $4.52 million.

BiotechMedtech
Sep'26
National Institutes of Health logo
Open

Alcohol Research-Related Resource Award

๐Ÿ‡บ๐Ÿ‡ธNIH ยท United States

Funds building a shared resource for the whole alcohol research field โ€” data, materials, tools or services. Hypothesis-driven research is explicitly out.

Biotech
Sep'26