NIH Small Business Innovation Research (SBIR) Phase IIB Strategic Breakthrough Award
Funds a small business already through NIH SBIR Phase II to cross the gap to commercialisation. A cost share is required.
There's a well-known hole in the small-business research funding path: an SBIR or STTR Phase II award proves a technology works, and then the money runs out just as commercialisation is starting. The Phase IIB Strategic Breakthrough award exists to bridge exactly that gap.
It gives a project that already holds an NIH SBIR or STTR Phase II award additional support for later-stage research and deve…
Later-stage research and development bridging the gap between the end of an NIH SBIR or STTR Phase II award and commercialisation, for United States small business concerns that already hold such an award.
Sign up free to see the funding breakdown
Sign up free to see the industries in scope
Sign up free to see the full eligibility
Sign up free to see how to apply
Sign up free to see what you submit
Sign up free to see how they score you
Sign up free to see the timeline
Sign up free to see where teams trip up
Guides for this application
All guides →SBIR/STTR Grants for Deeptech Startups
A practical guide to SBIR and STTR grants for deeptech startups, including agency fit, Phase I and II logic, eligibility, budgets, and review criteria.
DocumentsNIH Biosketch Guide: Format, SciENcv Steps, and Examples
Learn what an NIH biosketch is, how the format works, what to prepare for SciENcv, and how startup teams should avoid common biosketch mistakes.
Write proposalHow to Write a Specific Aims Page
Learn how to write a specific aims page for NIH, SBIR-adjacent, and translational R&D grants, with structure, reviewer logic, examples, and common mistakes.
Where to applyGrants for Biotech Startups: NIH, NSF, SBIR/STTR, and Non-Dilutive Funding
A practical guide to grants for biotech startups, including NIH SBIR/STTR, NSF, translational funding, evidence, regulatory readiness, and budgets.
More from NIMH
All grants from this funder →NIMH SBIR/STTR
🇺🇸NIMH · United States
Supports United States. small businesses building mental health technologies through recurring NIH pathways.
NIMH R01/R21/R03
🇺🇸NIMH · United States
Funds investigator-led mental health science in the United States through established and exploratory research projects.
Similar grants
Browse the directory →
NIMHD SBIR Phase IIB Strategic Breakthrough Award
🇺🇸NIMHD · United States
Funds prior NIH SBIR and STTR Phase II small businesses bridging later-stage R&D to commercialization.
NIAMS SBIR — Small Business Innovation Research
🇺🇸NIAMS · United States
Supports small businesses and researchers advancing arthritis, skin, and musculoskeletal innovation through staged aid.
NIH, CDC and FDA Small Business Innovation Research Grant
🇺🇸NIH · United States
Funds early feasibility work through late-stage R&D for a US small business turning a health science idea into a marketable product.
NIAAA SBIR/STTR — Small Business Alcohol Technology
🇺🇸NIAAA · United States
Supports small businesses creating alcohol-related diagnostics, treatment, and digital health tools.
NIH SBIR Phase II
🇺🇸NIH SEED · United States
Supports United States biomedical small businesses advancing successful feasibility work into scale-up development.
NIH SBIR Phase II (Omnibus)
🇺🇸NIH · United States
Funds United States small businesses advancing validated biomedical innovations through substantial full development execution.