NIH, CDC and FDA Small Business Innovation Research Grant
Funds early feasibility work through late-stage R&D for a US small business turning a health science idea into a marketable product.
A promising piece of health science does not turn itself into a product, and a small company rarely has the budget to make that leap on spec.
This is NIH's standing Small Business Innovation Research door for exactly that gap. It supports feasibility studies first, then the research and development a promising result needs to become a commercial product, across every participating NIH institute a…
Two-phase Small Business Innovation Research funding — feasibility studies followed by research and development — open to any United States small business concern developing a scientific innovation into a commercial product, across the National Institutes of Health, CDC and FDA missions. Clinical trials are optional.
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Guides for this application
All guides →SBIR/STTR Grants for Deeptech Startups
A practical guide to SBIR and STTR grants for deeptech startups, including agency fit, Phase I and II logic, eligibility, budgets, and review criteria.
DocumentsNIH Biosketch Guide: Format, SciENcv Steps, and Examples
Learn what an NIH biosketch is, how the format works, what to prepare for SciENcv, and how startup teams should avoid common biosketch mistakes.
Write proposalHow to Write a Specific Aims Page
Learn how to write a specific aims page for NIH, SBIR-adjacent, and translational R&D grants, with structure, reviewer logic, examples, and common mistakes.
Where to applyGrants for Biotech Startups: NIH, NSF, SBIR/STTR, and Non-Dilutive Funding
A practical guide to grants for biotech startups, including NIH SBIR/STTR, NSF, translational funding, evidence, regulatory readiness, and budgets.
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