Cellular and Molecular Biology of Complex Brain Disorders (R21)
Funds short, exploratory work on what genetic risk factors for brain disorders actually do inside cells and circuits.
Genetics has handed neuroscience a long list of risk factors for conditions like schizophrenia, autism and bipolar disorder. What it has not handed anyone is an explanation of what those factors actually do inside a cell. This notice funds that second question.
The focus is deliberately narrow and deliberately deep: the intracellular, transcellular and circuit machinery of neural function. Work c…
The biology of high-confidence genetic and environmental risk factors for complex brain disorders, focused on intracellular, transcellular and circuit mechanisms of neural function, using in vivo, in situ or in vitro systems including model organisms and human cell-based assays.
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