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NIH Small Research Grant Program

Pilot Projects Investigating Understudied Proteins Associated with Rare Diseases

Funds basic biochemical or biological work on a protein from a published list β€” druggable, linked to a rare disease, and barely studied.

OpenNational Institutes of HealthUnited States

Most biomedical research concentrates on a small number of well-known proteins. This notice deliberately funds work on the ones nobody has looked at.

The eligible proteins are not left to the applicant. A list is provided, and every protein on it meets two conditions: it belongs to a druggable protein family, and it has a known association with a rare disease. Druggable matters β€” the point is not…

Pilot projects generating preliminary data and tools to characterise understudied proteins from a published list of druggable protein family members with a known rare disease association, through basic biochemical and biological work. Clinical trials are not allowed.

CycleiHow often this grant runs β€” e.g. annually, on a rolling basis, or a one-off call.Multiple per year
Next deadlineiThe next date applications are due. Rolling means you can apply any time.16 Nov 2027
Decision timeiTypical time from the deadline to the funder's decision.26 weeks
Project durationiHow long the funded work is expected to run.β€”
Award typeiThe form of funding β€” grant, equity, loan, tax credit, etc.Grant
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.β€”
Funding pooliThe total budget available across all awards in this round.β€”

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Last verified: 25 Aug 2026Funder reference: PAR-25-122Source: www.grants.gov