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NIH Exploratory/Developmental Grants Phase II (R33)

Development of Psychosocial Therapeutic and Preventive Interventions for Mental Disorders (R33)

Funds three years replicating target engagement for a psychosocial intervention and testing whether that engagement tracks clinical change.

This notice sits at a precise point in the institute's pipeline: after a mechanism has been shown once, before anyone claims it explains the treatment's effect.

The interventions are psychosocial — therapeutic and preventive — for mental disorders. The stated purpose is speeding the translation of emerging research in basic, behavioural, cognitive, affective and neuropsychological science into in

Up to three years replicating target engagement from prior studies for psychosocial therapeutic and preventive interventions for mental disorders, and testing the association between target engagement and change in clinical outcomes, translating emerging basic, behavioural, cognitive, affective and neuropsychological science into interventions. A clinical trial is required.

CycleiHow often this grant runs — e.g. annually, on a rolling basis, or a one-off call.Multiple per year
Next deadlineiThe next date applications are due. Rolling means you can apply any time.15 Oct 2027
Decision timeiTypical time from the deadline to the funder's decision.26 weeks
Project durationiHow long the funded work is expected to run.
Award typeiThe form of funding — grant, equity, loan, tax credit, etc.Grant
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.
Funding pooliThe total budget available across all awards in this round.

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Last verified: 25 Aug 2026Funder reference: PAR-25-181Source: www.grants.gov