Enhancing Mechanistic Research on Precision Probiotic Therapies (R33)
Funds mechanistic work on the host biology that decides who responds to a probiotic and who does not.
Probiotic trials produce inconsistent results, and the usual explanation is that people differ. This notice funds turning that explanation into something measurable.
The goal is precision probiotic therapy: characterising person-specific features that affect probiotic response, so responders can be identified as a subgroup rather than discovered afterwards.
The host features named are wide and c…
Rigorously designed mechanistic studies, in animal models or human subjects, characterising person-specific host features — native microbiome, immune system, gender, diet, age, genetic background, lifestyle and health history — that affect probiotic response, to identify responder subgroups and address the heterogeneity causing inconsistent probiotic outcomes. Clinical trials are optional.
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