Enhancing Mechanistic Research on Precision Probiotic Therapies (R61/R33)
Funds two years finding the host biology behind inconsistent probiotic responses, then more to test whether those patterns actually predict who responds.
The phased version of the National Institutes of Health's precision probiotics notice, and the phasing maps neatly onto the two halves of the question.
The problem is that the same probiotic helps some people and not others, and trials come out inconsistent as a result. The notice treats that heterogeneity as the thing to explain rather than the noise to average out.
The first phase runs up to t…
Phased mechanistic research on precision probiotic therapy: a first phase of up to two years using observational or secondary data analysis to identify host biological patterns — native microbiome, immune system, gender, diet, age, genetic background, lifestyle and health history — correlated with heterogeneous probiotic effects, and a second phase testing whether those patterns detect improved probiotic responsiveness. Clinical trials are optional.
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