Avant Garde/Avenir Awards for Investigators Conducting High Risk/High Reward Research on HIV and Substance Use (or Substance Use Disorders)
Funds high-risk, high-reward research on HIV prevention, diagnosis or treatment in people who use substances or have a substance use disorder.
NIH runs a small set of awards for people, not just projects — betting on a scientist's potential rather than a fully worked-out plan. This notice is that bet, aimed specifically at HIV and substance use.
What it funds is innovative basic, clinical, translational, and implementation science research relevant to HIV and substance use. The explicit target is high risk, high impact, transformative w…
High risk, high impact, transformative basic, clinical, translational and implementation science research advancing HIV prevention, diagnosis, treatment and virus suppression in people who use substances or have a substance use disorder, funded as an individual-investigator award. Clinical trials are optional.
Sign up free to see the funding breakdown
Sign up free to see the industries in scope
Sign up free to see the full eligibility
Sign up free to see how to apply
Sign up free to see what you submit
Sign up free to see how they score you
Sign up free to see the timeline
Sign up free to see where teams trip up
Guides for this application
All guides →NIH Biosketch Guide: Format, SciENcv Steps, and Examples
Learn what an NIH biosketch is, how the format works, what to prepare for SciENcv, and how startup teams should avoid common biosketch mistakes.
Write proposalHow to Write a Specific Aims Page
Learn how to write a specific aims page for NIH, SBIR-adjacent, and translational R&D grants, with structure, reviewer logic, examples, and common mistakes.
Where to applyGrants for Biotech Startups: NIH, NSF, SBIR/STTR, and Non-Dilutive Funding
A practical guide to grants for biotech startups, including NIH SBIR/STTR, NSF, translational funding, evidence, regulatory readiness, and budgets.
DocumentsGrant Work Plan Template: Work Packages, Gantt, Milestones, and Risks
Use this grant work plan template to structure work packages, tasks, owners, deliverables, Gantt timing, dependencies, and risk registers.
More from NIH
All grants from this funder →GREGoRi Data Coordination and Outreach Center
🇺🇸NIH · United States
Funds the one centre that coordinates a rare-disease genomics programme and gets its protocols, data and tools out to everybody else.
GREGoRi Innovation Projects
NIH · United States
Funds a genuinely new experimental or computational approach to finding the cause of a rare genetic disorder, where the current state of the art falls short.
GREGoRi Technology Integration Center
🇺🇸NIH · United States
Funds the centre that turns new molecular methods for rare-disease diagnosis into standards, best practices and a benchmarking dataset.
Clinical Observational (CO) Studies in Musculoskeletal, Rheumatic, and Skin Diseases
🇺🇸NIH · United States
Funds studies that watch patients rather than treat them, in bone, joint, rheumatic and skin disease. No intervention allowed.
Exploratory Clinical Trial Grants in Arthritis and Musculoskeletal and Skin Diseases (R61)
🇺🇸NIH · United States
Funds early-stage clinical trials in arthritis, musculoskeletal and skin disease. A trial is compulsory.
Developing novel theory and methods for understanding the genetic architecture of complex human traits (R01)
NIH · United States
Funds theory and method development on how genetic and non-genetic factors together produce variation in complex traits, tested against large existing datasets.
Similar grants
Browse the directory →DoW Spinal Cord Injury, Investigator-Initiated Research Award
🇺🇸MRDC / CDMRP · United States
Funds spinal cord injury research from basic science through translation, open to investigators at any career stage.
DoW Parkinson's, Early Investigator Research Award
🇺🇸MRDC / CDMRP · United States
Funds early-career Parkinson's research, with a required mentor at the fellow level and none needed at the independent level.
DoW Parkinson's, Investigator-Initiated Research Award
🇺🇸MRDC / CDMRP · United States
Funds rigorous Parkinson's disease research for investigators at any career stage, with an optional second PI and clinical trials allowed.
DoW Vision, Investigator-Initiated Research Award
🇺🇸MRDC / CDMRP · United States
Funds basic-through-early-translational research on service-connected eye injury or visual dysfunction — clinical trials are not part of this one.
DoW Bone Marrow Failure, Investigator-Initiated Research Award
🇺🇸MRDC / CDMRP · United States
Funds mature bone marrow failure research, including drug-development groundwork, but not a clinical trial itself.
DoW Toxic Exposures Investigator Initiated Research Award
🇺🇸MRDC / CDMRP · United States
Funds basic-through-translational research on diseases linked to military-related toxic exposure, at almost any research stage short of a new clinical trial.