Integrated Specific Pathogen Free Research Models and Human New Approach Methodologies to Advance HIV/AIDS Research
Funds cooperative agreements pairing specific-pathogen-free animal colonies with human-based alternatives for HIV/AIDS research.
HIV/AIDS research still leans on specific pathogen free, or SPF, animal colonies for the questions no human-based method can yet answer — and NIH is simultaneously funding the tools meant to reduce that reliance. This notice funds both halves under one mechanism.
The NAMs-enabled component supports a stewardship framework: a triage and consultation service inside request intake and allocation, to…
Cooperative agreements combining two integrated priorities for NIH-funded HIV/AIDS research: a NAMs-enabled stewardship framework (triage and consultation to reduce or replace specific pathogen free, or SPF, in vivo model use, optional human in vitro HIV testing support, and pilot benchmarking) and support for high-quality SPF colony resources, including colony management, virologic surveillance and high-resolution immunogenetic characterisation, where in vivo models remain scientifically necessary. Clinical trials are not accepted.
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