Single Cell Opioid Responses in the Context of HIV (SCORCH) Program: Phase 2
Funds single-cell research into how opioid use and HIV interact in brain tissue, building on the SCORCH consortium's first phase.
Opioid use and HIV infection do not just occur in the same patients — they interact inside the same cells and circuits, and most of that interaction is invisible at the tissue level.
This is the second phase of the Single Cell Opioid Responses in the Context of HIV (SCORCH) consortium, which since 2020 has built single-nucleus datasets from human and animal postmortem brain tissue under HIV infec…
Single-cell and single-nucleus research into how HIV infection, antiretroviral therapy and substance exposure — including opioids, cocaine, methamphetamine and cannabinoids — interact at the subcellular, cellular and circuit level in the central nervous system, continuing the SCORCH consortium's Phase 1 postmortem brain-tissue datasets into new data-mining and hypothesis-driven studies.
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