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NIH Exploratory/Developmental Grants Phase II (R33)

Catalyze: Product Definition for Small Molecules, Biologics, and Combination Products - Preliminary Product/Lead Series Identification and Combination Product Prototype

Funds turning a preliminary drug, biologic or combination-product lead into a combination-product prototype for heart, lung, blood or sleep disease.

OpenNational Institutes of HealthUnited States

A preliminary lead compound is not a product yet — someone still has to build it into something that could plausibly become a combination product. This notice funds that build-out.

It sits inside NHLBI's Catalyze Program, and this specific initiative covers small molecules, biologics and combination products for heart, lung, blood and sleep disease. It funds the early translational work needed to…

Development of a preliminary product or lead series into a combination-product prototype for small molecule, biologic and combination-product candidates against heart, lung, blood or sleep disease, under NHLBI's Catalyze Program.

CycleiHow often this grant runs — e.g. annually, on a rolling basis, or a one-off call.Multiple per year
Next deadlineiThe next date applications are due. Rolling means you can apply any time.23 Dec 2027
Decision timeiTypical time from the deadline to the funder's decision.26 weeks
Project durationiHow long the funded work is expected to run.—
Award typeiThe form of funding — grant, equity, loan, tax credit, etc.Grant
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.—
Funding pooliThe total budget available across all awards in this round.—

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Last verified: 25 Aug 2026Funder reference: RFA-HL-26-018Source: www.grants.gov