HEAL Initiative: Optimization of Therapeutic Medical Devices through Team Science Mechanistic Research
Funds team science that works out how a therapeutic medical device produces its effect, covering both approved and investigational devices.
Medical devices are supposed to complement drugs and behavioral treatment, and often to do things neither can. But plenty of them show inconsistent results in preclinical studies, fail to translate to humans, or help some patients and not others — and a lot of that comes down to nobody fully understanding how the device produces its effect in the first place.
This notice funds finding that out. N…
Team-science research into the mechanisms of action of therapeutic medical devices — both investigational devices and devices already FDA-approved and in clinical use — aimed at identifying physiological markers of neurological conditions and how device-based therapies affect them. Supported approaches include mechanistic clinical trials, animal studies, and computational modeling or simulation.
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