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Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN) Infrastructure - Clinical Coordinating Center (CCC) and Data Coordinating Center (DCC)

Funds the operations hub and the data hub that keep NIH's emergency-care clinical trials network running.

Some of the most dangerous emergencies — non-stroke neurological and cardiovascular events — get treated in the back of an ambulance or in the first minutes of an ED visit, exactly where evidence about what actually helps is thinnest.

SIREN — the Strategies to Innovate EmeRgENcy Care Clinical Trials Network — exists to close that gap. Run jointly by NINDS and NHLBI, it performs clinical trials ai

Continuing infrastructure for the Strategies to Innovate EmeRgENcy Care Clinical Trials Network (SIREN), funding a Clinical Coordinating Center and a Data Coordinating Center to run and support trials that test treatments for non-stroke neurological and cardiovascular emergencies in the pre-hospital or emergency-department setting.

CycleiHow often this grant runs — e.g. annually, on a rolling basis, or a one-off call.No fixed schedule
Next deadlineiThe next date applications are due. Rolling means you can apply any time.4 Mar 2027
Decision timeiTypical time from the deadline to the funder's decision.26 weeks
Project durationiHow long the funded work is expected to run.
Award typeiThe form of funding — grant, equity, loan, tax credit, etc.Cooperative agreement
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.
Funding pooliThe total budget available across all awards in this round.

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Last verified: 25 Aug 2026Funder reference: RFA-NS-28-001Source: www.grants.gov