TOPx HHS Tech Sprint for AI and Invisible Illness — Impact Award
Pays $15,000 each to 15 teams for AI tools that improve detection or care for Lyme disease and invisible illness.
Runs in two phases: a non-monetary Team Mobilization round where a panel selects up to 15 teams per challenge area (up to 45 total, plus up to 15 alternates) from short concept proposals, then a TOPx Sprint round, roughly eleven weeks long, where advancing teams build and demo a working minimum viable product. Both phases are scored on the same 20-point rubric, split equally across four criteria: …
Open to individuals, teams and organizations that build AI-powered tools using U.S. Open Data to improve detection, care and understanding of hard-to-diagnose chronic conditions such as Lyme disease, Long COVID and other autoimmune illnesses. Entrants pick one of three challenge tracks: Lyme Innovation, Invisible Illness, or Cost of Illness. Entities must be U.S.-incorporated with a U.S. primary place of business, and individuals must be U.S. citizens or permanent residents aged 18 or over.
Sign up free to see the funding breakdown
Sign up free to see the industries in scope
Sign up free to see the full eligibility
Sign up free to see how to apply
Sign up free to see what you submit
Sign up free to see how they score you
Sign up free to see the timeline
Sign up free to see where teams trip up
Guides for this application
All guides →How to Write a Grant Proposal Reviewers Can Score
Learn how to write a grant proposal around reviewer criteria, evidence, work packages, budget logic, and commercialization for deeptech and R&D funding.
DocumentsGrant Work Plan Template: Work Packages, Gantt, Milestones, and Risks
Use this grant work plan template to structure work packages, tasks, owners, deliverables, Gantt timing, dependencies, and risk registers.
Write proposalGrant Concept Note Example: Pre-Proposal Structure for Startups
See a practical grant concept note example, with a worked deeptech pre-proposal, section map, invite-to-full logic, and reviewer checks.
DocumentsGrant Pitch Deck Example: Slides, Storyline, and Video Script
See a grant pitch deck example with slide outline, EIC-style pitch logic, demo-video script, and grant-vs-investor deck differences.
More from HHS
All grants from this funder →Title X Family Planning Services Grants
🇺🇸HHS · United States
Supports family planning service providers across United States jurisdictions with grants that strengthen sexual health prevention, testing, counseling, and care.
Making America Healthy Again — Dementia Disparities (OMH) — Seed
🇺🇸HHS · United States
Supports community-based teams reducing dementia and brain-health disparities in underserved groups through social-determinant-focused strategies.
Pregnancy and Postpartum Hypertension Control Initiative (OWH) — Seed
🇺🇸HHS · United States
Supports maternal health and blood pressure monitoring initiatives for underserved pregnant and postpartum populations through community-linked innovation.
LymeX Healthathon
🇺🇸HHS · United States
Pays a $250,000 prize pool for stories and insights from people living with Lyme disease.
LymeX Visible Voices Prize
🇺🇸HHS · United States
Pays up to $50,000 per prize from a $250,000 pool for Lyme disease education resources.
National Training Center for Teen Pregnancy Prevention
🇺🇸HHS · United States
Supports national-level teams delivering training and technical guidance to teen pregnancy prevention efforts across United States partners.
Similar grants
Browse the directory →Global Deep Tech Battle @ SLUSH 2026
swisstech · Switzerland
Awards a 3,000-euro cash prize to the winning deep-tech pitch at SLUSH 2026.
Childhood, Adolescent and Young Adult (AYA) Cancer Data Innovation Challenge — Track 1
🇺🇸NCI · United States
Pays entities up to $566,665 across three milestones to add shovel-ready cancer data or tools to NCI's CCDI ecosystem.
Improving Health Provider Hand Hygiene Challenge
🇺🇸IRC · United States
Awards up to $30,000 for hand-hygiene solutions built for low-resource healthcare settings.
Targeting RNA in Disease with Novel Technologies (TRDNT) Challenge
🇺🇸NIH · United States
Awards up to $13.1 million across three phases to US-based teams developing novel technologies that target RNA to treat human disease.
TRDNT Challenge Phase II: Prototype Development and Use Case Demonstration
🇺🇸NIH · United States
Pays up to $120,000 per Interim Milestone winner and up to $320,000 per Final Submission winner to US-based researchers, startups and institutions that build a working prototype technology able to target endogenous RNA in human disease.
Targeting RNA in Disease with Novel Technologies (TRDNT) Challenge – Phase I
🇺🇸NIH · United States
Paid up to $20,000 each to as many as 25 winners in Phase I of a three-phase NIH challenge for technologies that target RNA directly to treat human disease.