Expression of interest: Precision prevention: biological mechanisms of response variation
Funding for human studies of biological mechanisms in precision prevention.
This funding opportunity supports interventional studies in humans to validate a mechanistic hypothesis and directly interrogate the biological mechanisms governing the transition from health to early disease and the mechanisms underlying variation in response to biomedical prevention interventions.
Projects must involve an experimental investigation in humans at their core, designed to validate …
In scope are experimental investigations in humans that validate a mechanistic hypothesis in pre-disease, early stage or emerging disease, including a biomedical intervention or challenge with an established safety profile. Exploratory biomarker studies, biomarker discovery projects, observational studies involving no experimental challenge, animal experimental interventions or challenges, pre-clinical model development and validation, and projects focused on managing established disease rather than preventing its onset are ineligible.
Sign up free to see the funding breakdown
Sign up free to see the industries in scope
Sign up free to see the full eligibility
Sign up free to see how to apply
Sign up free to see what you submit
Sign up free to see how they score you
Sign up free to see the timeline
Sign up free to see where teams trip up
Guides for this application
All guides →Grants for Biotech Startups: NIH, NSF, SBIR/STTR, and Non-Dilutive Funding
A practical guide to grants for biotech startups, including NIH SBIR/STTR, NSF, translational funding, evidence, regulatory readiness, and budgets.
BudgetGrant Financials and Co-Funding Evidence: Examples for Startup Applications
See examples of grant financials, match funding evidence, co-funding tables, accountant letters, investor commitments, and budget-to-work-plan checks.
Write proposalHow to Write a Grant Proposal Reviewers Can Score
Learn how to write a grant proposal around reviewer criteria, evidence, work packages, budget logic, and commercialization for deeptech and R&D funding.
DocumentsGrant Work Plan Template: Work Packages, Gantt, Milestones, and Risks
Use this grant work plan template to structure work packages, tasks, owners, deliverables, Gantt timing, dependencies, and risk registers.
More from MRC
All grants from this funder →Collaborate with the UK Human Functional Genomics Initiative
🇬🇧MRC · United Kingdom
Test an academic-industry functional-genomics idea and generate early data.
UKRI translation: MRC proof of concept: stage two
🇬🇧MRC · United Kingdom
Funding for invited academic-led translational health projects.
MRC Equip
🇬🇧MRC · United Kingdom
Supports research equipment investments that expand laboratory capacity and strengthen translational health innovation.
UKRI Translation: MRC Impact Acceleration Awards
🇬🇧MRC · United Kingdom
Single-step support for high-risk medical product development.
UKRI Translation: MRC Proof of Concept: stage one
🇬🇧MRC · United Kingdom
Funding for academic-led development of novel health interventions.
UK Obesity Research Institute: full application
🇬🇧MRC · United Kingdom
Establish a collaborative institute for mechanistic obesity research.
Similar grants
Browse the directory →
Prevention and management of chronic non-communicable diseases in children and young people
🇪🇺European Commission · European Union
Funds implementation research that helps children and young people prevent and manage chronic disease equitably.
Clinical trials for advancing innovative interventions for neurodegenerative diseases
🇪🇺European Commission · European Union
Funds early clinical trials of safer, more effective interventions for non-rare neurodegenerative diseases.
Horizon Health: Bio-printing for Regenerative Medicine
🇪🇺European Commission · European Union
Funds €7–10M projects that advance living-cell bio-printing from laboratory proof toward regenerative medicine.
Innovative healthcare interventions for non-communicable diseases
🇪🇺European Commission · European Union
Funds €7–8M projects that validate innovative interventions for cardiovascular, metabolic, respiratory or kidney disease.
Warwick Innovations Proof of Concept Fund
🇬🇧Warwick Innovations · United Kingdom
Supports University of Warwick researchers with internal proof-of-concept funding so registered discoveries can move toward commercialization.
SFC Interface Innovation Vouchers
🇬🇧SFC · United Kingdom
Offers voucher-based projects so Scottish organizations can work with universities on urgent innovation needs.