DOE Office of Science logo
DOE Office of Science

FY 2026 Continuation of Solicitation for the Office of Science Financial Assistance Program

Funds DOE Office of Science research in computing, energy sciences, biology, fusion, high-energy and nuclear physics, and isotopes β€” open to any applicant type.

Between cyclesDOE Office of ScienceUnited States

The Department of Energy's Office of Science runs one open call covering its entire research portfolio, reissued every year rather than published as separate notices per topic.

Seven programme areas sit inside it: Advanced Scientific Computing Research, Basic Energy Sciences, Biological and Environmental Research, Fusion Energy Sciences, High Energy Physics, Nuclear Physics, and Isotope R&D and P…

DOE Office of Science's full annual research portfolio β€” Advanced Scientific Computing Research, Basic Energy Sciences, Biological and Environmental Research, Fusion Energy Sciences, High Energy Physics, Nuclear Physics, and Isotope R&D and Production β€” open to any applicant type, unrestricted.

CycleiHow often this grant runs - e.g. annually, on a rolling basis, or a one-off call.Annual
Next deadlineiThe next date applications are due. Rolling means you can apply any time.-
Decision timeiTypical time from the deadline to the funder's decision.-
Project durationiHow long the funded work is expected to run.-
Award typeiThe form of funding - grant, equity, loan, tax credit, etc.Cooperative agreement
Match fundingiThe share of project costs you must cover yourself. 0% = fully funded.-
Funding pooliThe total budget available across all awards in this round.$500M

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Guides for this application

All guides β†’
DOE Office of Science logo
Open

The Genesis Mission: AI for Science and Energy

πŸ‡ΊπŸ‡ΈDOE SC Β· United States

Provides research teams and institutions for The Genesis Mission: AI for Science and Energy in artificial intelligence, energy systems, and quantum systems.

AIEnergy Tech+1
Dec'26
DOE Office of Science logo
Open

The Genesis Mission: Transforming Science and Energy with AI

πŸ‡ΊπŸ‡ΈDOE SC Β· United States

Supports AI for science progress from early concept stages toward national-scale implementation.

AIEnergy Tech+5
Dec'26
DOE Office of Science logo
Open

Continuation of Solicitation for the DOE Office of Science Financial Assistance Program

πŸ‡ΊπŸ‡ΈDOE SC Β· United States

Supports unsolicited basic research proposals across all Office of Science thematic areas in the United States.

Energy TechAI+6
DOE Office of Science logo
Between cycles

DOE Early Career Research Program

πŸ‡ΊπŸ‡ΈDOE SC Β· United States

Funds research teams and institutions for DOE Early Career Research in energy systems, artificial intelligence, and quantum systems.

Energy TechAI+5
$875K – $2.8M
DOE Office of Science logo
Between cycles

DOE Energy Frontier Research Centers

πŸ‡ΊπŸ‡ΈDOE SC Β· United States

Backs research teams and institutions for DOE Energy Frontier Research Centers in energy systems, materials science, and quantum systems.

Energy TechAdvanced Materials+3
$12M – $16M
DOE Office of Science logo
Between cycles

Energy Frontier Research Centers β€” 8th Class

πŸ‡ΊπŸ‡ΈDOE SC Β· United States

Supports multidisciplinary research centers tackling fundamental energy science grand challenges.

Energy TechQuantum+5
$12M – $16M
DOE Fusion Energy Sciences logo
Open

Milestone-Based Fusion Development Program β€” Expansion

πŸ‡ΊπŸ‡ΈDOE FES Β· United States

Helps research teams and institutions for Milestone Based Fusion Development Expansion in energy systems and fusion research.

Energy TechFusion
$7.1M – $19.5M
DOE Fusion Energy Sciences logo
Open

INFUSE RFA Cycle

πŸ‡ΊπŸ‡ΈDOE FES Β· United States

Supports private fusion companies through annual partnerships with national laboratories.

FusionEnergy Tech+2
$100K – $500K
National Institutes of Health logo
Scheduled

Single Cell Opioid Responses in the Context of HIV (SCORCH) Program: Phase 2

πŸ‡ΊπŸ‡ΈNIH Β· United States

Funds single-cell research into how opioid use and HIV interact in brain tissue, building on the SCORCH consortium's first phase.

Biotech
$1MJun'27
Israel-U.S. Binational Industrial Research and Development Foundation logo
Open

BIRD General Program

πŸ‡ΊπŸ‡ΈBIRD Foundation Β· United States

Supports United States and Israel partners to jointly commercialize hi-tech innovation, including cybersecurity, life sciences, and manufacturing.

AgritechAI+13
$1.5MNov'26
Centers for Disease Control and Prevention logo
Open

Emerging Infections Network - Research for Preventing, Detecting, and Managing Travel-associated Infectious Diseases

πŸ‡ΊπŸ‡ΈCDC Β· United States

Funds surveillance and research networks that detect, diagnose and track infectious diseases among international travelers.

Biotech
$1.8M – $6MNov'26
National Institutes of Health logo
Open

GREGoRi Data Coordination and Outreach Center

πŸ‡ΊπŸ‡ΈNIH Β· United States

Funds the one centre that coordinates a rare-disease genomics programme and gets its protocols, data and tools out to everybody else.

BiotechAI
$1.3MOct'26