DoW Amyotrophic Lateral Sclerosis Research Program, Therapeutic Development Award
Funds preclinical-to-IND-enabling work on an ALS drug that already has proof-of-concept efficacy data and a lead compound in hand.
By the time a treatment reaches this award, the easy question — does it work at all, even a little — is supposed to already be answered. This funds the expensive middle stretch: turning a validated lead into something ready for an FDA Investigational New Drug application.
The bar to enter is concrete. An application needs a lead compound already in hand, with proof-of-concept efficacy data from a…
Preclinical-to-IND-enabling therapeutic development for ALS, entering with a lead compound already in hand and proof-of-concept efficacy data from at least one preclinical model, with mechanism-specific target-engagement and pharmacodynamic biomarker development run in parallel to improve trial design, patient selection or interpretation. Candidates that already hold an IND, and biomarkers not tied to the therapeutic programme, are out of scope.
Sign up free to see the funding breakdown
Sign up free to see the industries in scope
Sign up free to see the full eligibility
Sign up free to see how to apply
Sign up free to see how they score you
Sign up free to see the timeline
Sign up free to see where teams trip up
Guides for this application
All guides →Grants for Biotech Startups: NIH, NSF, SBIR/STTR, and Non-Dilutive Funding
A practical guide to grants for biotech startups, including NIH SBIR/STTR, NSF, translational funding, evidence, regulatory readiness, and budgets.
Submit & reportSAM.gov Registration and UEI Guide for Federal Grant Applicants
Learn how SAM.gov registration, UEI numbers, Grants.gov accounts, organization profiles, workspace roles, and renewal timing fit together.
Find grantsGovernment Grants for Startups: What Deeptech Founders Should Know
A practical guide to government grants for startups, including Grants.gov, SBIR/STTR, state programs, eligibility, fit, timelines, and when to apply.
BudgetIndirect Costs in Grants: Rates, MTDC, and Examples
Understand indirect costs in grants, including direct vs indirect costs, negotiated rates, de minimis rates, MTDC, funder caps, and budget narrative implications.
More from MRDC / CDMRP
All grants from this funder →DoW Arthritis Clinical Research Award
🇺🇸MRDC / CDMRP · United States
Funds a human study of arthritis at whichever of two scales the evidence supports — a pilot or a full trial.
DoW Arthritis Translational Research Award
🇺🇸MRDC / CDMRP · United States
Funds preclinical or animal arthritis research that's too applied to count as basic science and not yet ready for people.
DoW Autism Clinical Trial Award
🇺🇸MRDC / CDMRP · United States
Funds a clinical trial of a new autism treatment, product or device, from a small proof-of-concept study up to a full efficacy trial.
DoW Autism Idea Development Award
🇺🇸MRDC / CDMRP · United States
Funds an innovative, high-risk autism research idea aimed at a critical problem or need, before there's a trial to run.
DoW Tick-Borne Disease Idea Development Award
🇺🇸MRDC / CDMRP · United States
Funds a conceptually new, unproven idea in tick-borne disease research — not an incremental step on work that is already published or underway.
DoW Tick-Borne Disease Therapeutic/Diagnostic Research Award
🇺🇸MRDC / CDMRP · United States
Funds either a drug-discovery study or a clinical diagnostic approach for Lyme disease and other tick-borne diseases, aimed at something a clinic could use.
Similar grants
Browse the directory →
Focused Technology Research and Development
🇺🇸NIH · United States
Funds a project that develops a biomedical research technology and only that — no biological question attached.
SEED Research Program
🇺🇸UW Entrepreneurship Hub + WiSys · United States
Funds UW Madison spin-out research teams to advance commercialization through faculty-led projects.
NIDCD R21 Exploratory/Developmental Research Grant
🇺🇸NIDCD · United States
Supports early exploratory methods and technologies for communication science in the United States.
Basic Research Grant Program
🇺🇸AEDC · United States
Supports Arkansas institutions with matching grants for original-research costs and stronger academic enterprise collaboration.
Development of Animal Models and Related Biological Materials for Research
🇺🇸NIH · United States
Funds developing or improving animal models and related materials — but only where they serve several institutes and several body systems.
Bexar County Skills Development Program
🇺🇸Bexar Innovation Fund · United States
Funds Bexar County companies expanding targeted-industry jobs through workforce training grants.